Аннотация
A convenient and efficient method for the synthesis of polyfluorinated 2-mercaptobenzothiazoles from the corresponding aniline derivatives and CS2, mediated by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in toluene is described. The reaction proceeded via nucleophilic attack at the carbon atom of carbon disulfide by the nitrogen atom of NH2-group in arene followed by selective intramolecular fluorine atom substitution in the ortho-position to the amino group. This synthetic methodology could be used to prepare fluorinated 2-mercaptobenzothiazole containing alkynyl group in good to excellent yields. The reaction takes place under very mild reaction conditions (50 °C) and uses readily available starting materials.
Язык оригинала | английский |
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Страницы (с-по) | 130-136 |
Число страниц | 7 |
Журнал | Journal of Fluorine Chemistry |
Том | 212 |
DOI | |
Состояние | Опубликовано - 1 авг 2018 |
Предметные области OECD FOS+WOS
- 1.04 ХИМИЧЕСКИЕ НАУКИ