Highly efficient synthesis of novel fluorinated 3-amino-2-mercaptobenzothiazole-2(3H)-thione derivatives

Larisa Politanskaya, Irina Bagryanskaya, Evgeny Tretyakov, Chanjuan Xi

Результат исследования: Научные публикации в периодических изданияхстатья

Аннотация

Here, a convenient and efficient method for the synthesis of polyfluorinated 3-amino-2-mercaptobenzothiazole-2(3H)-thione derivatives from the corresponding arylhydrazines and CS2, mediated by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in acetonitrile is described. The reaction proceeded via selective intramolecular ortho-fluorine atom substitution by the S-nucleophilic center of the carbon disulfide molecule attached at the first stage of the reaction (a tandem process). The reaction takes place under mild reaction conditions (room temperature), has an excellent yield, and involves readily available starting materials.

Язык оригиналаанглийский
Номер статьи109628
ЖурналJournal of Fluorine Chemistry
Том239
DOI
СостояниеОпубликовано - ноя 2020

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