High-resolution MRI data of the brain of C57BL/6J and BTBR mice in three anatomical views

Yulia A. Ryabushkina, Oleg B. Shevelev, Polina E. Kisaretova, Nikita G. Sozonov, Kseniya A. Ayriyants, Natalya P. Bondar, Vasiliy V. Reshetnikov

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

The research on strain-, sex-, and stress-specific differences in structural and functional connectivity of the brain is important for elucidating various behavioral features and etiologies of psychiatric disorders. Socially impaired BTBR mice are considered a model of autism spectrum disorders. Here we present high-resolution magnetic resonance imaging data from the brain of 89 adolescent mice (C57BL/6J and BTBR) in axial, sagittal, and coronal views. The study [1] includes both females and males differed in early-life experience (normally reared or subjected to prolonged maternal separation: 3 h daily from postnatal day 2 to 15). The MRI data were obtained on a horizontal tomograph Biospec 117/16 instrument with a magnetic field strength of 11.7 T. Thus, multislice Turbo RARE T2-weighted images of the brain were captured in eight groups of mice. Altogether, these data allow to evaluate strain-, sex-, and stress-specific alterations in the volumes of various brain structures and to better understand the relation between brain structural differences and behavioral abnormalities.

Язык оригиналаанглийский
Номер статьи107619
ЖурналData in Brief
Том39
DOI
СостояниеОпубликовано - дек 2021

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