Аннотация
Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operable primary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31.7% vs. control (no treatment).
Язык оригинала | английский |
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Страницы (с-по) | 349-351 |
Число страниц | 3 |
Журнал | Bulletin of Experimental Biology and Medicine |
Том | 163 |
Номер выпуска | 3 |
DOI | |
Состояние | Опубликовано - 1 июл 2017 |