High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage

V. I. Kaledin, V. P. Nikolin, N. A. Popova, M. G. Klinnikova, L. A. Bogdanova, T. S. Morozkova

Результат исследования: Научные публикации в периодических изданияхстатья

1 Цитирования (Scopus)

Аннотация

Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operable primary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31.7% vs. control (no treatment).

Язык оригиналаанглийский
Страницы (с-по)349-351
Число страниц3
ЖурналBulletin of Experimental Biology and Medicine
Том163
Номер выпуска3
DOI
СостояниеОпубликовано - 1 июл 2017

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