High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage

V. I. Kaledin; V. P. Nikolin; N. A. Popova; M. G. Klinnikova; L. A. Bogdanova; T. S. Morozkova

doi:10.1007/s10517-017-3801-3

High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage

V. I. Kaledin, V. P. Nikolin, N. A. Popova, M. G. Klinnikova, L. A. Bogdanova, T. S. Morozkova

Кафедра цитологии и генетики ФЕН

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

1 Цитирования (Scopus)

Аннотация

Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operable primary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31.7% vs. control (no treatment).

Язык оригинала	английский
Страницы (с-по)	349-351
Число страниц	3
Журнал	Bulletin of Experimental Biology and Medicine
Том	163
Номер выпуска	3
DOI	https://doi.org/10.1007/s10517-017-3801-3
Состояние	Опубликовано - 1 июл 2017

Доступ к документу

10.1007/s10517-017-3801-3

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title = "High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage",

abstract = "Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operable primary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31.7% vs. control (no treatment).",

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author = "Kaledin, {V. I.} and Nikolin, {V. P.} and Popova, {N. A.} and Klinnikova, {M. G.} and Bogdanova, {L. A.} and Morozkova, {T. S.}",

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High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage. / Kaledin, V. I.; Nikolin, V. P.; Popova, N. A.; Klinnikova, M. G.; Bogdanova, L. A.; Morozkova, T. S.

В: Bulletin of Experimental Biology and Medicine, Том 163, № 3, 01.07.2017, стр. 349-351.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

TY - JOUR

T1 - High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage

AU - Kaledin, V. I.

AU - Nikolin, V. P.

AU - Popova, N. A.

AU - Klinnikova, M. G.

AU - Bogdanova, L. A.

AU - Morozkova, T. S.

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AB - Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operable primary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31.7% vs. control (no treatment).

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