Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals

Kirill V. Kovtunov, Larisa M. Kovtunova, Max E. Gemeinhardt, Andrey V. Bukhtiyarov, Jonathan Gesiorski, Valerii I. Bukhtiyarov, Eduard Y. Chekmenev, Igor V. Koptyug, Boyd M. Goodson

Результат исследования: Научные публикации в периодических изданияхстатья

30 Цитирования (Scopus)

Аннотация

The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3-bis(2,4,6-trimethylphenyl), imidazole-2-ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous SABRE (HET-SABRE) catalyst that was used to demonstrate a circa 100-fold enhancement of 15N NMR signals in 15N-pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No 15N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XPS characterization supports the fact that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst-free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.

Язык оригиналаанглийский
Страницы (с-по)10433-10437
Число страниц5
ЖурналAngewandte Chemie - International Edition
Том56
Номер выпуска35
DOI
СостояниеОпубликовано - 21 авг 2017

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  • Цитировать

    Kovtunov, K. V., Kovtunova, L. M., Gemeinhardt, M. E., Bukhtiyarov, A. V., Gesiorski, J., Bukhtiyarov, V. I., Chekmenev, E. Y., Koptyug, I. V., & Goodson, B. M. (2017). Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals. Angewandte Chemie - International Edition, 56(35), 10433-10437. https://doi.org/10.1002/anie.201705014