TY - JOUR
T1 - Halogenated (F, Cl) 1,3-benzodiazoles, 1,2,3-benzotriazoles, 2,1,3-benzothia(selena)diazoles and 1,4-benzodiazines inducing Hep2 cell apoptosis
AU - Prima, Darya O.
AU - Vorontsova, Elena V.
AU - Makarov, Arkady G.
AU - Makarov, Alexander Yu
AU - Bagryanskaya, Irina Yu
AU - Mikhailovskaya, Tatiana F.
AU - Slizhov, Yuri G.
AU - Zibarev, Andrey V.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - The title compounds synthesized from halogenated arene-1,2-diamines revealed, together with the latter, cytotoxicity towards the Hep2 (laryngeal epidermoid carcinoma) cells. The cytotoxicity was high and was accompanied by pronounced apoptotic activity at low concentrations for fluorinated diazoles, triazoles and selenadiazoles.
AB - The title compounds synthesized from halogenated arene-1,2-diamines revealed, together with the latter, cytotoxicity towards the Hep2 (laryngeal epidermoid carcinoma) cells. The cytotoxicity was high and was accompanied by pronounced apoptotic activity at low concentrations for fluorinated diazoles, triazoles and selenadiazoles.
UR - http://www.scopus.com/inward/record.url?scp=85030125084&partnerID=8YFLogxK
U2 - 10.1016/j.mencom.2017.09.002
DO - 10.1016/j.mencom.2017.09.002
M3 - Article
AN - SCOPUS:85030125084
VL - 27
SP - 439
EP - 442
JO - Mendeleev Communications
JF - Mendeleev Communications
SN - 0959-9436
IS - 5
ER -