Germline-restricted chromosome (GRC) is widespread among songbirds

Anna A. Torgasheva, Lyubov P. Malinovskaya, Kira S. Zadesenets, Tatyana V. Karamysheva, Elena A. Kizilova, Ekaterina A. Akberdina, Inna E. Pristyazhnyuk, Elena P. Shnaider, Valeria A. Volodkina, Alsu F. Saifitdinova, Svetlana A. Galkina, Denis M. Larkin, Nikolai B. Rubtsov, Pavel M. Borodin

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

14 Цитирования (Scopus)


An unusual supernumerary chromosome has been reported for two related avian species, the zebra and Bengalese finches. This large, germline-restricted chromosome (GRC) is eliminated from somatic cells and spermatids and transmitted via oocytes only. Its origin, distribution among avian lineages, and function were mostly unknown so far. Using immunolocalization of key meiotic proteins, we found that GRCs of varying size and genetic content are present in all 16 songbird species investigated and absent from germline genomes of all eight examined bird species from other avian orders. Results of fluorescent in situ hybridization of microdissected GRC probes and their sequencing indicate that GRCs show little homology between songbird species and contain a variety of repetitive elements and unique sequences with paralogs in the somatic genome. Our data suggest that the GRC evolved in the common ancestor of all songbirds and underwent significant changes in the extant descendant lineages.

Язык оригиналаанглийский
Страницы (с-по)11845-11850
Число страниц6
ЖурналProceedings of the National Academy of Sciences of the United States of America
Номер выпуска24
СостояниеОпубликовано - 11 июн 2019


Подробные сведения о темах исследования «Germline-restricted chromosome (GRC) is widespread among songbirds». Вместе они формируют уникальный семантический отпечаток (fingerprint).