The paper considers a regional model of the geological structure and oil and gas prospects of the Paleozoic sediments of the southeast of Western Siberia. The oil source rocks and types of Paleozoic oil and gas prospective objects in rocks of different composition are analyzed; seismogeological criteria for their identification are formulated. As a result of a complex interpretation of all geological and geophysical data on the territory of the south of Tomsk and the north of the Novosibirsk regions, the following results were obtained: structural map on the top of the pre-Jurassic basement; fault scheme; maps of magnetic and gravitational anomalies and material composition; field models and a map of oil and gas potential. The source rock in the Paleozoic, were both continental deposits of the basal Jurassic horizons and intra-Paleozoic marine source rock. Outstanding interest in the formation of reservoirs and the oil and gas potential of the Paleozoic formations is represented by organogenic limestones and dolomites of the indigenous Paleozoic and argillaceous-siliceous rocks of the weathering crust.