Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype

Andrey D. Manakhov, Maria Yu Mintseva, Igor A. Andreev, Lev I. Uralsky, Tatiana V. Andreeva, Oleg V. Trapezov, Evgeny I. Rogaev

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Over 35 fur colours have been described in American mink (Neovison vison), only six of which have been previously linked to specific genes. Moyle fur colour belongs to a wide group of brownish colours that are highly similar to each other, which complicates selection and breeding procedures. We performed whole genome sequencing for two American minks with Moyle (m/m) and Violet (a/a m/m /p/p) phenotypes. We identified two frame-shift mutations in the gene encoding Ras-related protein-38 (RAB38), which regulates the trafficking of tyrosinase-containing vesicles to maturing melanosomes. The results highlight the role of RAB38 in the biogenesis of melanosomes and melanin and the genetic mechanism contributing to hair colour variety and intensity. These data are also useful for tracking economically valuable fur traits in mink breeding programmes.

Язык оригиналаанглийский
Номер статьи15876
Число страниц6
ЖурналScientific Reports
Том10
Номер выпуска1
DOI
СостояниеОпубликовано - 1 дек 2020

Fingerprint Подробные сведения о темах исследования «Genome analysis of American minks reveals link of mutations in Ras-related protein-38 gene to Moyle brown coat phenotype». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать