@article{ad22312b5e814631af79738219d58b09,
title = "Generation of two spinal muscular atrophy (SMA) type I patient-derived induced pluripotent stem cell (iPSC) lines and two SMA type II patient-derived iPSC lines",
abstract = "Spinal muscular atrophy (SMA) is a neuromuscular disease caused by deletion or mutation in SMN1 gene. SMA human induced pluripotent stem cells (iPSCs) represent a useful and valid model for the study of the disorder, as they provide in vitro the target cells. We generated iPSCs from a SMA type I patient and SMA type II patient by using non-integrating episomal plasmid vectors. The resulting iPSCs are episomal-free, express pluripotency markers, display a normal karyotype, retain the mutation (homozygous deletion of SMN1) and are able to differentiate into the three germ layers.",
keywords = "BLOOD, Cell Line, Cell Culture Techniques/methods, Humans, Adult, Induced Pluripotent Stem Cells/pathology, Child, Muscular Atrophy, Spinal/pathology",
author = "Valetdinova, {K. R.} and Maretina, {M. A.} and Kuranova, {M. L.} and Grigor'eva, {E. V.} and Minina, {Y. M.} and Kizilova, {E. A.} and Kiselev, {A. V.} and Medvedev, {S. P.} and Baranov, {V. S.} and Zakian, {S. M.}",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Elsevier B.V. All rights reserved.",
year = "2019",
month = jan,
day = "1",
doi = "10.1016/j.scr.2018.101376",
language = "English",
volume = "34",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier",
}