Generation of two iPSC lines (IMGTi001-A and IMGTi001-B) from human skin fibroblasts with ring chromosome 22

T. V. Nikitina, A. G. Menzorov, A. A. Kashevarova, M. M. Gridina, A. A. Khabarova, Yu S. Yakovleva, M. E. Lopatkina, E. A. Kizilova, S. A. Vasilyev, O. L. Serov, I. N. Lebedev

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

1 Цитирования (Scopus)

Аннотация

Skin fibroblasts from a patient with intellectual disability and ring chromosome 22 were reprogrammed into induced pluripotent stem cells (iPSCs) to establish a clonal stem cell lines, IMGTi001-A (iTAF5-29) and IMGTi001-B (iTAF5-32). Because of ring chromosome mitotic instability these cell lines show mosaic karyotypes with 46,XX,r(22) in >83% cells, 45,XX,-22 as minor class and sporadically cells with other karyotypes. Differentiation in derivatives of all three germ layers was shown in teratoma assay for IMGTi001-A, and in embryoid bodies for both cell lines. To our knowledge, human iPSC lines with ring chromosome are described for the first time.

Язык оригиналаанглийский
Страницы (с-по)244-248
Число страниц5
ЖурналStem Cell Research
Том31
DOI
СостояниеОпубликовано - 1 авг 2018

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