@article{e2b3bb6e4f8f4994bdbda9ead28c9641,
title = "Generation of induced pluripotent stem cell line, ICGi034-A, by reprogramming peripheral blood mononuclear cells from a patient with Parkinson's disease associated with GBA mutation",
abstract = "Mutation in the glucocerebrosidase encoding gene (GBA) is one of the most frequent genetic cause of Parkinson's disease. ICGi034-A induced pluripotent stem cell (iPSC) line obtained by reprogramming peripheral blood mononuclear cells (PBMCs) of a patient with heterozygous c.1226A > G (p.N370S) mutation in the GBA gene can be used for studying the fundamental mechanisms of the pathogenesis of GBA-associated Parkinson's disease, and for potential drug screening. The iPSCs express pluripotency markers (NANOG, SSEA4, TRA-1-60, OCT4, SOX2), have a normal karyotype, and are capable of producing derivatives of three germ layers.",
author = "Grigor'eva, {Elena V.} and Drozdova, {Elena S.} and Sorogina, {Diana A.} and Malakhova, {Anastasia A.} and Pavlova, {Sofia V.} and Vyatkin, {Yuri V.} and Khabarova, {Elena A.} and Rzaev, {Jamil A.} and Medvedev, {Sergey P.} and Zakian, {Suren M.}",
note = "Funding Information: This study was supported by the Russian Science Foundation , grant № 19-75-20063 . FSBI Federal Neurosurgical Center provided PBMCs of Parkinson{\textquoteright}s disease patient. Clinical exome sequencing was analysed in Novosibirsk State University. The mouse embryonic fibroblasts were obtained at the Common Facilities Centre “SPF-vivarium of the ICG SB RAS” (https://ckp.icgen.ru/spf/). The immunofluorescent imaging was performed using resources of the Common Facilities Center of Microscopic Analysis of Biological Objects, ICG SB RAS (https://ckp.icgen.ru/ckpmabo/), supported by the State project of the Institute of Cytology and Genetics (# 0259-2021-0011). Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = mar,
doi = "10.1016/j.scr.2021.102651",
language = "English",
volume = "59",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier",
}