Generation of induced pluripotent stem cell line, ICGi007-A, by reprogramming peripheral blood mononuclear cells from a patient with Huntington's disease

E. V. Grigor'eva, T. B. Malankhanova, A. Surumbayeva, J. M. Minina, V. V. Morozov, N. Yu Abramycheva, S. N. Illarioshkin, A. A. Malakhova, S. M. Zakian

Результат исследования: Научные публикации в периодических изданияхстатья

4 Цитирования (Scopus)

Аннотация

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by mutation in the HTT gene encoding HTT protein. The mutant protein leads to the neuronal death through dysregulation of multiple cellular processes. HD human induced pluripotent stem cells (iPSCs) represent a useful and valid model for the disease study. iPSC line from HD patient with 47 CAG repeats in HTT was generated from blood mononuclear cells by non-integrating episomal vectors. The iPSC line retained the mutation, expressed pluripotency markers, had a normal karyotype and displayed in vitro differentiation to the three germ layers.

Язык оригиналаанглийский
Номер статьи101382
Число страниц5
ЖурналStem Cell Research
Том34
DOI
СостояниеОпубликовано - 1 янв 2019

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