Generation of a spinal muscular atrophy type III patient-specific induced pluripotent stem cell line ICGi003-A

V. S. Ovechkina; M. A. Maretina; A. A. Egorova; V. S. Baranov; A. V. Kiselev; S. M. Zakian; K. R. Valetdinova

doi:10.1016/j.scr.2020.101938

Generation of a spinal muscular atrophy type III patient-specific induced pluripotent stem cell line ICGi003-A

V. S. Ovechkina, M. A. Maretina, A. A. Egorova, V. S. Baranov, A. V. Kiselev, S. M. Zakian, K. R. Valetdinova

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

Аннотация

Spinal muscular atrophy (SMA) is a genetic disease, which characterized by the degeneration of motor neurons in the spinal cord and further striated muscle atrophy. The research of the processes in diseased neurons is complicated due to the impossibility of obtaining them safely from patients. Thus, we generated SMA type III induced pluripotent stem cell lines via using non-integrated episomal plasmid vectors. The resulting cell line expresses the major pluripotency markers and can differentiate in vitro into derivatives of three germ layers. The iPSC line can be used for further studies by providing in vitro the relevant cell types.

Язык оригинала	английский
Номер статьи	101938
Число страниц	4
Журнал	Stem Cell Research
Том	48
Ранняя дата в режиме онлайн	3 авг. 2020
DOI	https://doi.org/10.1016/j.scr.2020.101938
Состояние	Опубликовано - 1 окт. 2020

Предметные области OECD FOS+WOS

1.06.DR КЛЕТОЧНАЯ БИОЛОГИЯ
2.08.DB БИОТЕХНОЛОГИЯ И ПРИКЛАДНАЯ МИКРОБИОЛОГИЯ

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10.1016/j.scr.2020.101938

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title = "Generation of a spinal muscular atrophy type III patient-specific induced pluripotent stem cell line ICGi003-A",

abstract = "Spinal muscular atrophy (SMA) is a genetic disease, which characterized by the degeneration of motor neurons in the spinal cord and further striated muscle atrophy. The research of the processes in diseased neurons is complicated due to the impossibility of obtaining them safely from patients. Thus, we generated SMA type III induced pluripotent stem cell lines via using non-integrated episomal plasmid vectors. The resulting cell line expresses the major pluripotency markers and can differentiate in vitro into derivatives of three germ layers. The iPSC line can be used for further studies by providing in vitro the relevant cell types.",

author = "Ovechkina, {V. S.} and Maretina, {M. A.} and Egorova, {A. A.} and Baranov, {V. S.} and Kiselev, {A. V.} and Zakian, {S. M.} and Valetdinova, {K. R.}",

note = "Funding Information: The reported study was funded by RFBR, project number 20-34-70019. Partial support from the Ministry of Science and Higher Education of the Russian Federation via D.O. Ott RIOG&R, project number AAAA-A19-119021290033-1 is also acknowleged. Publisher Copyright: {\textcopyright} 2020 The Authors Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = oct,

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doi = "10.1016/j.scr.2020.101938",

language = "English",

volume = "48",

journal = "Stem Cell Research",

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Generation of a spinal muscular atrophy type III patient-specific induced pluripotent stem cell line ICGi003-A. / Ovechkina, V. S.; Maretina, M. A.; Egorova, A. A. и др.

В: Stem Cell Research, Том 48, 101938, 01.10.2020.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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AU - Ovechkina, V. S.

AU - Maretina, M. A.

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AU - Baranov, V. S.

AU - Kiselev, A. V.

AU - Zakian, S. M.

AU - Valetdinova, K. R.

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PY - 2020/10/1

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AB - Spinal muscular atrophy (SMA) is a genetic disease, which characterized by the degeneration of motor neurons in the spinal cord and further striated muscle atrophy. The research of the processes in diseased neurons is complicated due to the impossibility of obtaining them safely from patients. Thus, we generated SMA type III induced pluripotent stem cell lines via using non-integrated episomal plasmid vectors. The resulting cell line expresses the major pluripotency markers and can differentiate in vitro into derivatives of three germ layers. The iPSC line can be used for further studies by providing in vitro the relevant cell types.

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