Fused in sarcoma (FUS) in dna repair: Tango with poly(ADP-ribose) polymerase 1 and compartmentalisation of damaged DNA

Maria V. Sukhanova, Anastasia S. Singatulina, David Pastré, Olga I. Lavrik

Результат исследования: Научные публикации в периодических изданияхобзорная статьярецензирование

2 Цитирования (Scopus)

Аннотация

The fused in sarcoma (FUS) protein combines prion-like properties with a multifunctional DNA/RNA-binding domain and has functions spanning the regulation of RNA metabolism, including transcription, pre-mRNA splicing, mRNA transport and translation. In addition to its roles in RNA metabolism, FUS is implicated in the maintenance of DNA integrity. In this review, we examine the participation of FUS in major DNA repair pathways, focusing on DNA repair associated with poly(ADP-ribosyl)ation events and on how the interaction of FUS with poly(ADP-ribose) may orchestrate transient compartmentalisation of DNA strand breaks. Unravelling how prion-like RNA-binding proteins control DNA repair pathways will deepen our understanding of the pathogenesis of some neurological diseases and cancer as well as provide the basis for the development of relevant innovative therapeutic technologies. This knowledge may also extend the range of applications of poly(ADP-ribose) polymerase inhibitors to the treatment of neurodegenerative diseases related to RNA-binding proteins in the cell, e.g., amyotrophic lateral sclerosis and frontotemporal lobar degeneration.

Язык оригиналаанглийский
Номер статьи7020
Страницы (с-по)1-18
Число страниц18
ЖурналInternational Journal of Molecular Sciences
Том21
Номер выпуска19
DOI
СостояниеОпубликовано - 1 окт 2020
Опубликовано для внешнего пользованияДа

Fingerprint

Подробные сведения о темах исследования «Fused in sarcoma (FUS) in dna repair: Tango with poly(ADP-ribose) polymerase 1 and compartmentalisation of damaged DNA». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать