From Specific γ-CD/[Nb6Cl12(H2O)6]2+ Recognition to Biological Activity Tuning

Anton A. Ivanov; Tatiana N. Pozmogova; Anastasiya O. Solovieva; Tatiana S. Frolova; Olga I. Sinitsyna; Olga V. Lundovskaya; Alphiya R. Tsygankova; Mohamed Haouas; David Landy; Enrico Benassi; Lidiya V. Shestopalova; Clément Falaise; Emmanuel Cadot; Michael A. Shestopalov; Pavel A. Abramov; Maxim N. Sokolov

doi:10.1002/chem.202000739

From Specific γ-CD/[Nb₆Cl₁₂(H₂O)₆]²⁺ Recognition to Biological Activity Tuning

Anton A. Ivanov, Tatiana N. Pozmogova, Anastasiya O. Solovieva, Tatiana S. Frolova, Olga I. Sinitsyna, Olga V. Lundovskaya, Alphiya R. Tsygankova, Mohamed Haouas, David Landy, Enrico Benassi, Lidiya V. Shestopalova, Clément Falaise, Emmanuel Cadot, Michael A. Shestopalov, Pavel A. Abramov, Maxim N. Sokolov

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

2 Цитирования (Scopus)

Аннотация

Specific molecular recognition of γ-cyclodextrin (γ-CD) by the cationic hexanuclear niobium [Nb₆Cl₁₂(H₂O)₆]²⁺ cluster complex in aqueous solutions results in a 1:1 supramolecular assembly {[Nb₆Cl₁₂(H₂O)₆]@γ-CD}²⁺. NMR spectroscopy, isothermal titration calorimetry (ITC), and ESI-MS were used to study the interaction between the inorganic cluster and the organic macrocycle. Such molecular association affects the biological activity of [Nb₆Cl₁₂(H₂O)₆]²⁺, decreasing its cytotoxicity despite enhanced cellular uptake. The 1:1 stoichiometry is maintained in solution over a large window of the reagents’ ratio, but crystallization by slow evaporation produces a 1:2 host–guest complex [Nb₆Cl₁₂(H₂O)₆@(γ-CD)₂]Cl₂⋅20 H₂O featuring the cluster encapsulated between two molecules of γ-CD. The 1:2 complex was characterized by XRD, elemental analysis, IR spectroscopy, and thermogravimetric analysis (TGA). Quantum chemical calculations were performed to model host–guest interaction.

Язык оригинала	английский
Страницы (с-по)	7479-7485
Число страниц	7
Журнал	Chemistry - A European Journal
Том	26
Номер выпуска	33
DOI	https://doi.org/10.1002/chem.202000739
Состояние	Опубликовано - 10 июн. 2020

Доступ к документу

10.1002/chem.202000739

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Ivanov, A. A., Pozmogova, T. N., Solovieva, A. O., Frolova, T. S., Sinitsyna, O. I., Lundovskaya, O. V., Tsygankova, A. R., Haouas, M., Landy, D., Benassi, E., Shestopalova, L. V., Falaise, C., Cadot, E., Shestopalov, M. A., Abramov, P. A., & Sokolov, M. N. (2020). From Specific γ-CD/[Nb₆Cl₁₂(H₂O)₆]²⁺ Recognition to Biological Activity Tuning. Chemistry - A European Journal, 26(33), 7479-7485. https://doi.org/10.1002/chem.202000739

@article{01a71d2fa8a447398b3fbdfb417f60c7,

title = "From Specific γ-CD/[Nb6Cl12(H2O)6]2+ Recognition to Biological Activity Tuning",

abstract = "Specific molecular recognition of γ-cyclodextrin (γ-CD) by the cationic hexanuclear niobium [Nb6Cl12(H2O)6]2+ cluster complex in aqueous solutions results in a 1:1 supramolecular assembly {[Nb6Cl12(H2O)6]@γ-CD}2+. NMR spectroscopy, isothermal titration calorimetry (ITC), and ESI-MS were used to study the interaction between the inorganic cluster and the organic macrocycle. Such molecular association affects the biological activity of [Nb6Cl12(H2O)6]2+, decreasing its cytotoxicity despite enhanced cellular uptake. The 1:1 stoichiometry is maintained in solution over a large window of the reagents{\textquoteright} ratio, but crystallization by slow evaporation produces a 1:2 host–guest complex [Nb6Cl12(H2O)6@(γ-CD)2]Cl2⋅20 H2O featuring the cluster encapsulated between two molecules of γ-CD. The 1:2 complex was characterized by XRD, elemental analysis, IR spectroscopy, and thermogravimetric analysis (TGA). Quantum chemical calculations were performed to model host–guest interaction.",

keywords = "cluster compounds, cytotoxicity, gamma-cyclodextrin, genotoxicity, niobium, LUMINESCENCE, CLUSTER COMPLEXES, STABILITY, BETA-CYCLODEXTRIN, FORMULATION, BINDING, AZO-DYE",

author = "Ivanov, {Anton A.} and Pozmogova, {Tatiana N.} and Solovieva, {Anastasiya O.} and Frolova, {Tatiana S.} and Sinitsyna, {Olga I.} and Lundovskaya, {Olga V.} and Tsygankova, {Alphiya R.} and Mohamed Haouas and David Landy and Enrico Benassi and Shestopalova, {Lidiya V.} and Cl{\'e}ment Falaise and Emmanuel Cadot and Shestopalov, {Michael A.} and Abramov, {Pavel A.} and Sokolov, {Maxim N.}",

year = "2020",

month = jun,

day = "10",

doi = "10.1002/chem.202000739",

language = "English",

volume = "26",

pages = "7479--7485",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "Wiley-VCH Verlag",

number = "33",

}

Ivanov, AA, Pozmogova, TN, Solovieva, AO, Frolova, TS , Sinitsyna, OI, Lundovskaya, OV, Tsygankova, AR, Haouas, M, Landy, D, Benassi, E, Shestopalova, LV, Falaise, C, Cadot, E, Shestopalov, MA, Abramov, PA & Sokolov, MN 2020, 'From Specific γ-CD/[Nb₆Cl₁₂(H₂O)₆]²⁺ Recognition to Biological Activity Tuning', Chemistry - A European Journal, том. 26, № 33, стр. 7479-7485. https://doi.org/10.1002/chem.202000739

From Specific γ-CD/[Nb₆Cl₁₂(H₂O)₆]²⁺ Recognition to Biological Activity Tuning. / Ivanov, Anton A.; Pozmogova, Tatiana N.; Solovieva, Anastasiya O. и др.

В: Chemistry - A European Journal, Том 26, № 33, 10.06.2020, стр. 7479-7485.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

TY - JOUR

T1 - From Specific γ-CD/[Nb6Cl12(H2O)6]2+ Recognition to Biological Activity Tuning

AU - Ivanov, Anton A.

AU - Pozmogova, Tatiana N.

AU - Solovieva, Anastasiya O.

AU - Frolova, Tatiana S.

AU - Sinitsyna, Olga I.

AU - Lundovskaya, Olga V.

AU - Tsygankova, Alphiya R.

AU - Haouas, Mohamed

AU - Landy, David

AU - Benassi, Enrico

AU - Shestopalova, Lidiya V.

AU - Falaise, Clément

AU - Cadot, Emmanuel

AU - Shestopalov, Michael A.

AU - Abramov, Pavel A.

AU - Sokolov, Maxim N.

PY - 2020/6/10

Y1 - 2020/6/10

N2 - Specific molecular recognition of γ-cyclodextrin (γ-CD) by the cationic hexanuclear niobium [Nb6Cl12(H2O)6]2+ cluster complex in aqueous solutions results in a 1:1 supramolecular assembly {[Nb6Cl12(H2O)6]@γ-CD}2+. NMR spectroscopy, isothermal titration calorimetry (ITC), and ESI-MS were used to study the interaction between the inorganic cluster and the organic macrocycle. Such molecular association affects the biological activity of [Nb6Cl12(H2O)6]2+, decreasing its cytotoxicity despite enhanced cellular uptake. The 1:1 stoichiometry is maintained in solution over a large window of the reagents’ ratio, but crystallization by slow evaporation produces a 1:2 host–guest complex [Nb6Cl12(H2O)6@(γ-CD)2]Cl2⋅20 H2O featuring the cluster encapsulated between two molecules of γ-CD. The 1:2 complex was characterized by XRD, elemental analysis, IR spectroscopy, and thermogravimetric analysis (TGA). Quantum chemical calculations were performed to model host–guest interaction.

AB - Specific molecular recognition of γ-cyclodextrin (γ-CD) by the cationic hexanuclear niobium [Nb6Cl12(H2O)6]2+ cluster complex in aqueous solutions results in a 1:1 supramolecular assembly {[Nb6Cl12(H2O)6]@γ-CD}2+. NMR spectroscopy, isothermal titration calorimetry (ITC), and ESI-MS were used to study the interaction between the inorganic cluster and the organic macrocycle. Such molecular association affects the biological activity of [Nb6Cl12(H2O)6]2+, decreasing its cytotoxicity despite enhanced cellular uptake. The 1:1 stoichiometry is maintained in solution over a large window of the reagents’ ratio, but crystallization by slow evaporation produces a 1:2 host–guest complex [Nb6Cl12(H2O)6@(γ-CD)2]Cl2⋅20 H2O featuring the cluster encapsulated between two molecules of γ-CD. The 1:2 complex was characterized by XRD, elemental analysis, IR spectroscopy, and thermogravimetric analysis (TGA). Quantum chemical calculations were performed to model host–guest interaction.

KW - cluster compounds

KW - cytotoxicity

KW - gamma-cyclodextrin

KW - genotoxicity

KW - niobium

KW - LUMINESCENCE

KW - CLUSTER COMPLEXES

KW - STABILITY

KW - BETA-CYCLODEXTRIN

KW - FORMULATION

KW - BINDING

KW - AZO-DYE

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U2 - 10.1002/chem.202000739

DO - 10.1002/chem.202000739

M3 - Article

C2 - 32181923

AN - SCOPUS:85084972064

VL - 26

SP - 7479

EP - 7485

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 33