18 Цитирования (Scopus)


Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6I8}(DMSO)6](NO3)4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.

Язык оригиналаанглийский
Страницы (с-по)17915-17920
Число страниц6
ЖурналChemistry - A European Journal
Номер выпуска68
СостояниеОпубликовано - 17 дек 2018


Подробные сведения о темах исследования «From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis». Вместе они формируют уникальный семантический отпечаток (fingerprint).