@article{9104c1a554da4bef99935468a776ec13,
title = "From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis",
abstract = "Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6I8}(DMSO)6](NO3)4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.",
keywords = "cluster compounds, cytotoxicity, hydrolysis, molybdenum, tungsten, ONE-POT SYNTHESIS, ER STRESS, ENDOPLASMIC-RETICULUM STRESS, OXYGEN, NANOPARTICLES, POLYSTYRENE, COMPLEXES SYNTHESIS, HEXANUCLEAR MOLYBDENUM, LUMINESCENCE, GENERATION, Photosensitizing Agents/chemistry, Humans, Cell Survival/drug effects, Photochemical Processes, Light, Drug Stability, Models, Molecular, Neoplasms/drug therapy, Tungsten/chemistry, Molybdenum/chemistry, Antineoplastic Agents/chemistry, Hep G2 Cells, Hydrolysis, Cell Line, Tumor",
author = "Svezhentseva, {Ekaterina V.} and Vorotnikov, {Yuri A.} and Solovieva, {Anastasiya O.} and Pozmogova, {Tatiana N.} and Eltsov, {Ilia V.} and Ivanov, {Anton A.} and Evtushok, {Darya V.} and Miroshnichenko, {Svetlana M.} and Yanshole, {Vadim V.} and Eling, {Charlotte J.} and Adawi, {Ali M.} and Bouillard, {Jean Sebastien G.} and Kuratieva, {Natalia V.} and Fufaeva, {Maria S.} and Shestopalova, {Lidiya V.} and Mironov, {Yuri V.} and Efremova, {Olga A.} and Shestopalov, {Michael A.}",
note = "{\textcopyright} 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2018",
month = dec,
day = "17",
doi = "10.1002/chem.201804663",
language = "English",
volume = "24",
pages = "17915--17920",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "68",
}