Fluorine-Containing n-6 and Angular and Linear n-6-n’ (n, n’ = 5, 6, 7) Diaza-Heterocyclic Scaffolds Assembled on Benzene Core in Unified Way

Darya O. Prima, Arkady G. Makarov, Irina Yu Bagryanskaya, Andrey E. Kolesnikov, Leila V. Zargarova, Dmitry S. Baev, Tatiana F. Eliseeva, Larisa V. Politanskaya, Alexander Yu Makarov, Yuri G. Slizhov, Andrey V. Zibarev

Результат исследования: Научные публикации в периодических изданияхстатья

4 Цитирования (Scopus)

Аннотация

The title compounds, including hybrids (n ≠ n’), were assembled on benzene core in a unified way based on only one starting material C 6 F 5 NH 2 and a limited number of simple substitution and condensation reactions. The heterocyclic moieties were 1,3-diazoles, 1,2,3-triazoles, 1,2,5-thia(selena)diazoles, 1.4-diazines and 1,5-diazepines, as well as 1,3,2-dioxaboroles. Representatives of all new scaffolds were characterized by XRD. Compounds synthesized are of biomedical interest in the context of apoptotic anticancer activity, and the 1,2,5-thiadiazole/1,3,2-dioxaborole hybrid also in that of neutron or/and proton capture therapy of cancer. New 1,2,5-chalcogenadiazoles are protected forms of otherwise hardly accessible fluorine-containing di- and tetra-amines for further syntheses.

Язык оригиналаанглийский
Страницы (с-по)2383-2386
Число страниц4
ЖурналChemistrySelect
Том4
Номер выпуска8
DOI
СостояниеОпубликовано - 28 фев 2019

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