Flow synthesis of secondary amines over Ag/Al2O3 catalyst by one-pot reductive amination of aldehydes with nitroarenes

Ekaterina A. Artiukha, Alexey L. Nuzhdin, Galina A. Bukhtiyarova, Valerii I. Bukhtiyarov

Результат исследования: Научные публикации в периодических изданияхстатья

7 Цитирования (Scopus)

Аннотация

An alumina-supported silver catalyst was investigated in the one-pot reductive amination of aldehydes with nitroarenes in a continuous flow reactor using molecular hydrogen as a reducing agent. A series of secondary amines containing alkyl, OH, OCH3, Cl, Br and CC groups was synthesized in good to excellent yields. The yield of the secondary amine depends on the rate of formation of an intermediate imine. It was shown that the accumulation of carbonaceous deposits on the catalyst is the main reason of catalyst deactivation. The spent catalyst can be easily regenerated and reused without losing catalytic activity.

Язык оригиналаанглийский
Страницы (с-по)45856-45861
Число страниц6
ЖурналRSC Advances
Том7
Номер выпуска72
DOI
СостояниеОпубликовано - 1 янв 2017

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