Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution

Dudari B. Burueva, Alexey S. Romanov, Oleg G. Salnikov, Vladimir V. Zhivonitko, Yu Wen Chen, Danila A. Barskiy, Eduard Y. Chekmenev, Dennis W. Hwang, Kirill V. Kovtunov, Igor V. Koptyug

Результат исследования: Научные публикации в периодических изданияхстатья

11 Цитирования (Scopus)

Аннотация

Hyperpolarized (HP) propane produced by the parahydrogen-induced polarization (PHIP) technique has been recently introduced as a promising contrast agent for functional lung magnetic resonance (MR) imaging. However, its short lifetime due to a spin-lattice relaxation time T1 of less than 1 s in the gas phase is a significant translational challenge for its potential biomedical applications. The previously demonstrated approach for extending the lifetime of the HP propane state through long-lived spin states allows the HP propane lifetime to be increased by a factor of ∼3. Here, we demonstrate that a remarkable increase in the propane hyperpolarization decay time at high magnetic field (7.1 T) can be achieved by its dissolution in deuterated organic solvents (acetone-d6 or methanol-d4). The approximate values of the HP decay time for propane dissolved in acetone-d6 are 35.1 and 28.6 s for the CH2 group and the CH3 group, respectively (similar values were obtained for propane dissolved in methanol-d4), which are ∼50 times larger than the gaseous propane T1 value. Furthermore, we show that it is possible to retrieve HP propane from solution to the gas phase with the preservation of hyperpolarization.

Язык оригиналаанглийский
Страницы (с-по)4481-4487
Число страниц7
ЖурналJournal of Physical Chemistry C
Том121
Номер выпуска8
DOI
СостояниеОпубликовано - 2 мар 2017

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  • Цитировать

    Burueva, D. B., Romanov, A. S., Salnikov, O. G., Zhivonitko, V. V., Chen, Y. W., Barskiy, D. A., Chekmenev, E. Y., Hwang, D. W., Kovtunov, K. V., & Koptyug, I. V. (2017). Extending the Lifetime of Hyperpolarized Propane Gas through Reversible Dissolution. Journal of Physical Chemistry C, 121(8), 4481-4487. https://doi.org/10.1021/acs.jpcc.7b00509