Experimental substantiation of transdermal transportof photosensitizers by fractional laser photothermolysis (FLP)

As known photodynamic therapy and photothermolysis are used to treat skin diseases and to correct signs of aging. These methods are minimally invasive but their disadvantages are related to skin damage, prolonged phototoxicity with intravenous photosensitizer, and the insufficient penetration of the drug through the skin by local application. The possibility of minimally invasive transdermal drug transport by using photothermolysis and photodynamic therapy technologies on the example of the delivery of the Radagel photosensitizer has been demonstrated. The method of transdermal delivery of a photosensitizer through the skin micropores, which are formed by focused energy rays of a non- ablative laser has been developed for the side effects prevention of laser techniques with the summation of their advantages.