@article{45cd9b2f082648e8aff493081ca5db74,
title = "Experimental comparison of the in vivo efficacy of two novel anticancer therapies",
abstract = "Background/Aim: We compared the therapeutic efficacy of two recently developed experimental anticancer technologies: 1) in situ vaccination based on local immunotherapy with CpG oligonucleotides and anti-OX40 antibodies to activate antitumor immune response and 2) {"}Karanahan{"} technology [from the Sanskrit kāraa ('source') + han ('to kill')] based on the combined injection of cyclophosphamide and double-stranded DNA to eradicate cancer stem cells. Materials and Methods: The anticancer approaches were compared on three types of mouse malignant tumors with different grades of immunogenicity: weakly immunogenic carcinoma Krebs-2, moderately immunogenic Lewis carcinoma, and highly immunogenic A20 B-cellular lymphoma. Results: Our results indicated that in situ vaccination was the most effective against the highly immunogenic tumor A20. In addition, {"}Karanahan{"} demonstrated high efficiency in all types of tumors, regardless of their immunogenicity or size. Conclusion: {"}Karanahan{"} therapy showed higher efficacy relative to in situ vaccination with CpG oligonucleotides and anti-OX40 antibodies.",
keywords = "Anti-OX40 antibody, CpG oligonucleotides, Cyclophosphamide, Double-stranded DNA, Karanahan technology, Antigens, Neoplasm/immunology, Immunotherapy/methods, Male, Oligodeoxyribonucleotides/immunology, Cyclophosphamide/immunology, Antibodies/immunology, DNA/immunology, Lymphoma/immunology, Mice, Inbred CBA, Female, Carcinoma, Lewis Lung/immunology, Receptors, OX40/immunology, Mice, Inbred C57BL, Antigens, Differentiation/immunology, Antineoplastic Agents/immunology, Vaccination/methods, Neoplastic Stem Cells/immunology, Animals, Cell Line, Tumor, Mice, Mice, Inbred BALB C",
author = "Ruzanova, {Vera S.} and Proskurina, {Anastasia S.} and Ritter, {Genrikh S.} and Efremov, {Yaroslav R.} and Nikolin, {Valeriy P.} and Popova, {Nelly A.} and Naprimerov, {Vasiliy A.} and Dolgova, {Evgenia V.} and Potter, {Ekaterina A.} and Kirikovich, {Svetlana S.} and Levites, {Evgeniy V.} and Mustafin, {Zakhar S.} and Lashin, {Sergey A.} and Burakova, {Ekaterina A.} and Stetsenko, {Dmitry A.} and Ostanin, {Alexandr A.} and Chernykh, {Elena R.} and Bogachev, {Sergey S.}",
note = "Funding Information: The work was supported by the Russian Ministry of Science and High Education via the Institute of Cytology and Genetics (state budget project No 0259-2021-0013) and Russian Foundation for Basic Research (grant No 18-29-09045). Publisher Copyright: {\textcopyright} 2021 International Institute of Anticancer Research. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jul,
doi = "10.21873/anticanres.15125",
language = "English",
volume = "41",
pages = "3371--3387",
journal = "Anticancer research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "7",
}