Аннотация
Chimeric antigen receptors (CARs) are recombinant protein molecules that redirect cytotoxic lymphocytes toward malignant and other target cells. The high feasibility of manufacturing CAR-modified lymphocytes for the therapy of cancer has spurred the development and optimization of new CAR T cells directed against a broad range of target antigens. In this review, we describe the main structural and functional elements constituting a CAR, discuss the roles of these elements in modulating the anti-tumor activity of CAR T cells, and highlight alternative approaches to CAR engineering.
Язык оригинала | английский |
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Страницы (с-по) | 6-14 |
Число страниц | 9 |
Журнал | Acta Naturae |
Том | 9 |
Номер выпуска | 1 |
DOI | |
Состояние | Опубликовано - 1 янв 2017 |