Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy

S. A. Uspenskii, P. A. Khaptakhanova, A. A. Zaboronok, T. S. Kurkin, O. Yu Volkova, L. V. Mechetina, A. V. Taranin, V. V. Kanygin, Matsumura Akira, S. Yu Taskaev

Результат исследования: Научные публикации в периодических изданияхстатья

Аннотация

A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability.

Язык оригиналаанглийский
Страницы (с-по)45-48
Число страниц4
ЖурналDoklady Chemistry
Том491
Номер выпуска1
DOI
СостояниеОпубликовано - 1 мар 2020

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