Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma

Ekaterina A. Potter, Anastasia S. Proskurina, Genrikh S. Ritter, Evgenia V. Dolgova, Valeriy P. Nikolin, Nelly A. Popova, Oleg S. Taranov, Yaroslav R. Efremov, Sergey I. Bayborodin, Aleksandr A. Ostanin, Elena R. Chernykh, Nikolay A. Kolchanov, Sergey S. Bogachev

Результат исследования: Научные публикации в периодических изданияхстатья

4 Цитирования (Scopus)

Аннотация

Krebs-2 solid carcinoma was cured using a new "3+1" strategy for eradication of Krebs-2 tumor-initiating stem cells. This strategy was based on synchronization of these cells in a treatment-sensitive phase of the cell cycle. The synchronization mechanism, subsequent destruction of Krebs-2 tumor-initiating stem cells, and cure of mice from a solid graft were found to depend on the temporal profile of the interstrand cross-link repair cycle. Also, the temporal profile of the Krebs-2 interstrand repair cycle was found to have a pronounced seasonal cyclicity at the place of experiments (Novosibirsk, Russia). As a result, the therapeutic effect that is based on application of the described strategy, originally developed for the "winter repair cycle" (November- April), is completely eliminated in the summer period (June-September). We conclude that ?ne of the possible and the likeliest reasons for our failure to observe the therapeutic effects was the seasonal cyclicity in the duration of the interstrand repair cycle, the parameter that is central to our strategy.

Язык оригиналаанглийский
Страницы (с-по)28486-28499
Число страниц14
ЖурналOncotarget
Том9
Номер выпуска47
DOI
СостояниеОпубликовано - 19 июн 2018

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  • Цитировать

    Potter, E. A., Proskurina, A. S., Ritter, G. S., Dolgova, E. V., Nikolin, V. P., Popova, N. A., Taranov, O. S., Efremov, Y. R., Bayborodin, S. I., Ostanin, A. A., Chernykh, E. R., Kolchanov, N. A., & Bogachev, S. S. (2018). Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma. Oncotarget, 9(47), 28486-28499. https://doi.org/10.18632/oncotarget.25503