Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin

L. V. Yanshole; V. V. Yanshole; O. A. Snytnikova; A. Zh Fursova; N. G. Kolosova; Yu P. Tsentalovich; R. Z. Sagdeev

doi:10.1134/S1607672915050191

Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin

Переведенное название: Влияние глазных капель SkQ1 на метаболомный состав крысиного хрусталика и на шаперонную активность альфа-кристаллина

L. V. Yanshole, V. V. Yanshole, O. A. Snytnikova, A. Zh Fursova, N. G. Kolosova, Yu P. Tsentalovich, R. Z. Sagdeev

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

3 Цитирования (Scopus)

Аннотация

Лечение быстро стареющих крыс линии OXYS глазными каплями SkQ1 привело к задержке развития катаракты и значительному улучшению состояния хрусталика. Сравнение шаперонной активности альфа-кристаллинов, выделенных из крысиных хрусталиков, не выявило существенной разницы между крысами, получавшими SkQ1, и контрольными животными. Различия в содержании основных метаболитов (23 соединения) в хрусталиках крыс, получавших SkQ1, и контрольных крыс также были недостоверны.

Переведенное название	Влияние глазных капель SkQ1 на метаболомный состав крысиного хрусталика и на шаперонную активность альфа-кристаллина
Язык оригинала	английский
Номер статьи	21
Страницы (с-по)	341-345
Число страниц	5
Журнал	Doklady Biochemistry and Biophysics
Том	464
Номер выпуска	1
DOI	https://doi.org/10.1134/S1607672915050191
Состояние	Опубликовано - 1 сент. 2015

Предметные области OECD FOS+WOS

1.06 БИОЛОГИЧЕСКИЕ НАУКИ
1.04 ХИМИЧЕСКИЕ НАУКИ

ГРНТИ

31 ХИМИЯ

Доступ к документу

10.1134/S1607672915050191

Другие файлы и ссылки

Fingerprint

Подробные сведения о темах исследования «Влияние глазных капель SkQ1 на метаболомный состав крысиного хрусталика и на шаперонную активность альфа-кристаллина». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать

@article{5985c7b78fb44f14bf5be4237beda723,

title = "Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin",

abstract = "The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of α-crystallins isolated from the rat lenses did not reveal significant difference between SkQ1-treated and control rats. The contents of major metabolites (23 compounds) in lenses of SkQ1-treated and untreated rats are also very similar, though the concentration of reduced glutathione (GSH) in lenses of SkQ1-treated rats is 12% lower. This difference may be attributed to the reduction of the oxidative stress under action of SkQ1 eye drops, and to the decreased requirement to produce high amounts of this antioxidant.",

author = "Yanshole, {L. V.} and Yanshole, {V. V.} and Snytnikova, {O. A.} and Fursova, {A. Zh} and Kolosova, {N. G.} and Tsentalovich, {Yu P.} and Sagdeev, {R. Z.}",

note = "Publisher Copyright: {\textcopyright} 2015, Pleiades Publishing, Ltd.",

year = "2015",

month = sep,

day = "1",

doi = "10.1134/S1607672915050191",

language = "English",

volume = "464",

pages = "341--345",

journal = "Doklady Biochemistry and Biophysics",

issn = "1607-6729",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "1",

}

Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin. / Yanshole, L. V.; Yanshole, V. V.; Snytnikova, O. A. и др.

В: Doklady Biochemistry and Biophysics, Том 464, № 1, 21, 01.09.2015, стр. 341-345.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

TY - JOUR

T1 - Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of α-crystallin

AU - Yanshole, L. V.

AU - Yanshole, V. V.

AU - Snytnikova, O. A.

AU - Fursova, A. Zh

AU - Kolosova, N. G.

AU - Tsentalovich, Yu P.

AU - Sagdeev, R. Z.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of α-crystallins isolated from the rat lenses did not reveal significant difference between SkQ1-treated and control rats. The contents of major metabolites (23 compounds) in lenses of SkQ1-treated and untreated rats are also very similar, though the concentration of reduced glutathione (GSH) in lenses of SkQ1-treated rats is 12% lower. This difference may be attributed to the reduction of the oxidative stress under action of SkQ1 eye drops, and to the decreased requirement to produce high amounts of this antioxidant.

AB - The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of α-crystallins isolated from the rat lenses did not reveal significant difference between SkQ1-treated and control rats. The contents of major metabolites (23 compounds) in lenses of SkQ1-treated and untreated rats are also very similar, though the concentration of reduced glutathione (GSH) in lenses of SkQ1-treated rats is 12% lower. This difference may be attributed to the reduction of the oxidative stress under action of SkQ1 eye drops, and to the decreased requirement to produce high amounts of this antioxidant.

UR - http://www.scopus.com/inward/record.url?scp=84945576281&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=24967776

U2 - 10.1134/S1607672915050191

DO - 10.1134/S1607672915050191

M3 - Article

C2 - 26518564

AN - SCOPUS:84945576281

VL - 464

SP - 341

EP - 345

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

M1 - 21

ER -