Effect of SkQ1 eye drops on the rat lens metabolomic composition and the chaperone activity of alpha-crystallin

L. V. Yanshole, V. V. Yanshole, O. A. Snytnikova, A. Zh. Fursova, N. G. Kolosova, Yu. P. Tsentalovich, R. Z. Sagdeev

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

3 Цитирования (Scopus)

Аннотация

The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of alpha-crystallins isolated from the rat lenses did not reveal significant difference between SkQ1-treated and control rats. The contents of major metabolites (23 compounds) in lenses of SkQ1-treated and untreated rats are also very similar, though the concentration of reduced glutathione (GSH) in lenses of SkQ1-treated rats is 12% lower. This difference may be attributed to the reduction of the oxidative stress under action of SkQ1 eye drops, and to the decreased requirement to produce high amounts of this antioxidant.

Язык оригиналаанглийский
Страницы (с-по)341-345
Число страниц5
ЖурналDoklady Biochemistry and Biophysics
Том464
Номер выпуска1
DOI
СостояниеОпубликовано - сен 2015

Предметные области OECD FOS+WOS

  • 1.06 БИОЛОГИЧЕСКИЕ НАУКИ
  • 1.04 ХИМИЧЕСКИЕ НАУКИ

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