Effect of hypomorphic mutation in Trithorax-like gene on Drosophila melanogaster oogenesis

A. A. Ogienko, D. A. Karagodin, S. A. Fedorova, E. V. Fedorova, V. V. Lashina, E. M. Baricheva

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

7 Цитирования (Scopus)


We generated and characterized a new hypomorphic mutation of Drosophila melanogaster Trithorax-like (Trl) gene named Trl362. The Trl362 homozygous females are sterile and lay a small number of eggs; most embryos die at the early developmental stages. The transcriptional Trl level of adult Trl362 females was markedly lowered. Little or no GAGA protein, encoded by Trl@, was detected in the nurse cell nuclei. The ovaries of Trl362 females showed impairments, such considerable changes in the structure of both ovarioles and individual egg chambers. We believe that the observed ovarian defects in Trl362 mutants are mostly due to a decreased amount of GAGA protein in the germline cells. An increase of GAGA-519 protein caused by introduction of hsp83:GAGA-519 transgene against Trl362 background rescued partially the female fertility. It may well be that a decrease of GAGA protein in Trl362 germline cells leads to a defective expression of the genes regulated by transcription factor GAGA, whose products are essential for normal Drosophila oogenesis.

Язык оригиналаанглийский
Страницы (с-по)211-220
Число страниц10
Номер выпуска3
СостояниеОпубликовано - мая 2006
Опубликовано для внешнего пользованияДа


Подробные сведения о темах исследования «Effect of hypomorphic mutation in Trithorax-like gene on Drosophila melanogaster oogenesis». Вместе они формируют уникальный семантический отпечаток (fingerprint).