Effect of ball-milling on the formation of betulin and betulin diacetate composites with polyethylene glycol

Tatyana P. Shakhtshneider; Mikhail A. Mikhailenko; Valeri A. Drebushchak; Tatiana N. Drebushchak; Yuri N. Malyard; Svetlana A. Kuznetsova

doi:10.1016/j.matpr.2019.03.068

Effect of ball-milling on the formation of betulin and betulin diacetate composites with polyethylene glycol

Tatyana P. Shakhtshneider, Mikhail A. Mikhailenko, Valeri A. Drebushchak, Tatiana N. Drebushchak, Yuri N. Malyard, Svetlana A. Kuznetsova

Результат исследования: Научные публикации в периодических изданиях › статья по материалам конференции › рецензирование

1 Цитирования (Scopus)

Аннотация

Betulin and betulin diacetate (BDA) composites with polyethylene glycol (PEG) were obtained by ball-milling. In case of betulin - PEG mixtures, there was almost complete amorphization under ball-milling. On the contrary, there were no significant changes in the intensity of the reflections in the powder X-ray diffraction patterns for ball-milled mixtures of BDA with PEG. Dissolution of BDA in PEG melts formed at the contacts of particles under collisions with milling bodies leading to crystallization of the drug was suggested. An opportunity to dissolve BDA crystals in PEG melt followed by their crystallization was proven by DSC and hot stage optical microscopic observation.

Язык оригинала	английский
Страницы (с-по)	78-81
Число страниц	4
Журнал	Materials Today: Proceedings
Том	12
DOI	https://doi.org/10.1016/j.matpr.2019.03.068
Состояние	Опубликовано - 1 янв. 2019
Событие	5th International Conference on Fundamental Bases of Mechanochemical Technologies (FBMT) - Novosibirsk Продолжительность: 25 июн. 2018 → 28 июн. 2018

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10.1016/j.matpr.2019.03.068

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@article{1d007a8db030494fb62c64807d66e2f6,

title = "Effect of ball-milling on the formation of betulin and betulin diacetate composites with polyethylene glycol",

abstract = "Betulin and betulin diacetate (BDA) composites with polyethylene glycol (PEG) were obtained by ball-milling. In case of betulin - PEG mixtures, there was almost complete amorphization under ball-milling. On the contrary, there were no significant changes in the intensity of the reflections in the powder X-ray diffraction patterns for ball-milled mixtures of BDA with PEG. Dissolution of BDA in PEG melts formed at the contacts of particles under collisions with milling bodies leading to crystallization of the drug was suggested. An opportunity to dissolve BDA crystals in PEG melt followed by their crystallization was proven by DSC and hot stage optical microscopic observation.",

keywords = "betulin, betulin diacetate, PEG, ball-milling, composite formation, amorphization, melting, crystallization, Betulin, Melting, Ball-milling, Amorphization, Crystallization, Betulin diacetate, Composite formation",

author = "Shakhtshneider, {Tatyana P.} and Mikhailenko, {Mikhail A.} and Drebushchak, {Valeri A.} and Drebushchak, {Tatiana N.} and Malyard, {Yuri N.} and Kuznetsova, {Svetlana A.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd. All rights reserved.; 5th International Conference on Fundamental Bases of Mechanochemical Technologies (FBMT) ; Conference date: 25-06-2018 Through 28-06-2018",

year = "2019",

month = jan,

day = "1",

doi = "10.1016/j.matpr.2019.03.068",

language = "English",

volume = "12",

pages = "78--81",

journal = "Materials Today: Proceedings",

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}

Effect of ball-milling on the formation of betulin and betulin diacetate composites with polyethylene glycol. / Shakhtshneider, Tatyana P.; Mikhailenko, Mikhail A.; Drebushchak, Valeri A. и др.

В: Materials Today: Proceedings, Том 12, 01.01.2019, стр. 78-81.

Результат исследования: Научные публикации в периодических изданиях › статья по материалам конференции › рецензирование

TY - JOUR

T1 - Effect of ball-milling on the formation of betulin and betulin diacetate composites with polyethylene glycol

AU - Shakhtshneider, Tatyana P.

AU - Mikhailenko, Mikhail A.

AU - Drebushchak, Valeri A.

AU - Drebushchak, Tatiana N.

AU - Malyard, Yuri N.

AU - Kuznetsova, Svetlana A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Betulin and betulin diacetate (BDA) composites with polyethylene glycol (PEG) were obtained by ball-milling. In case of betulin - PEG mixtures, there was almost complete amorphization under ball-milling. On the contrary, there were no significant changes in the intensity of the reflections in the powder X-ray diffraction patterns for ball-milled mixtures of BDA with PEG. Dissolution of BDA in PEG melts formed at the contacts of particles under collisions with milling bodies leading to crystallization of the drug was suggested. An opportunity to dissolve BDA crystals in PEG melt followed by their crystallization was proven by DSC and hot stage optical microscopic observation.

AB - Betulin and betulin diacetate (BDA) composites with polyethylene glycol (PEG) were obtained by ball-milling. In case of betulin - PEG mixtures, there was almost complete amorphization under ball-milling. On the contrary, there were no significant changes in the intensity of the reflections in the powder X-ray diffraction patterns for ball-milled mixtures of BDA with PEG. Dissolution of BDA in PEG melts formed at the contacts of particles under collisions with milling bodies leading to crystallization of the drug was suggested. An opportunity to dissolve BDA crystals in PEG melt followed by their crystallization was proven by DSC and hot stage optical microscopic observation.

KW - betulin

KW - betulin diacetate

KW - PEG

KW - ball-milling

KW - composite formation

KW - amorphization

KW - melting

KW - crystallization

KW - Betulin

KW - Melting

KW - Ball-milling

KW - Amorphization

KW - Crystallization

KW - Betulin diacetate

KW - Composite formation

UR - http://www.scopus.com/inward/record.url?scp=85080114583&partnerID=8YFLogxK

U2 - 10.1016/j.matpr.2019.03.068

DO - 10.1016/j.matpr.2019.03.068

M3 - Conference article

VL - 12

SP - 78

EP - 81

JO - Materials Today: Proceedings

JF - Materials Today: Proceedings

SN - 2214-7853

T2 - 5th International Conference on Fundamental Bases of Mechanochemical Technologies (FBMT)

Y2 - 25 June 2018 through 28 June 2018

ER -