Diversity of cis-regulatory elements associated with auxin response in Arabidopsis thaliana

Pavel Cherenkov, Daria Novikova, Nadya Omelyanchuk, Victor Levitsky, Ivo Grosse, Dolf Weijers, Victoria Mironova

Результат исследования: Научные публикации в периодических изданияхстатья

16 Цитирования (Scopus)


The phytohormone auxin regulates virtually every developmental process in land plants. This regulation is mediated via de-repression of DNA-binding auxin response factors (ARFs). ARFs bind TGTC-containing auxin response cis-elements (AuxREs), but there is growing evidence that additional cis-elements occur in auxin-responsive regulatory regions. The repertoire of auxin-related cis-elements and their involvement in different modes of auxin response are not yet known. Here we analyze the enrichment of nucleotide hexamers in upstream regions of auxin-responsive genes associated with auxin up-or down-regulation, with early or late response, ARF-binding domains, and with different chromatin states. Intriguingly, hexamers potentially bound by basic helix-loop-helix (bHLH) and basic leucine zipper (bZIP) factors as well as a family of A/T-rich hexamers are more highly enriched in auxin-responsive regions than canonical TGTC-containing AuxREs. We classify and annotate the whole spectrum of enriched hexamers and discuss their patterns of enrichment related to different modes of auxin response.

Язык оригиналаанглийский
Страницы (с-по)329-339
Число страниц11
ЖурналJournal of Experimental Botany
Номер выпуска2
СостояниеОпубликовано - 4 янв 2018

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