Discrepancy between thermodynamic and kinetic stabilities of the: Tert -butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

Результат исследования: Научные публикации в периодических изданияхстатья

5 Цитирования (Scopus)

Аннотация

The tert-butanol (TBA)-water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).

Язык оригиналаанглийский
Страницы (с-по)4262-4265
Число страниц4
ЖурналChemical Communications
Том55
Номер выпуска29
DOI
СостояниеОпубликовано - 17 апр 2019

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