Аннотация
The tert-butanol (TBA)-water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).
Язык оригинала | английский |
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Страницы (с-по) | 4262-4265 |
Число страниц | 4 |
Журнал | Chemical Communications |
Том | 55 |
Номер выпуска | 29 |
DOI | |
Состояние | Опубликовано - 17 апр 2019 |