Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor

Anastasiya S. Sokolova; Olga I. Yarovaya; Nikolay I. Bormotov; Larisa N. Shishkina; Nariman F. Salakhutdinov

doi:10.1002/cbdv.201800153

Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor

Anastasiya S. Sokolova, Olga I. Yarovaya, Nikolay I. Bormotov, Larisa N. Shishkina, Nariman F. Salakhutdinov

Лаборатория новых медицинских препаратов ИМПЗ

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

12 Цитирования (Scopus)

Аннотация

A series of the bornyl ester/amide derivatives with N-containing heterocycles were designed and synthesized as vaccinia virus (VV) inhibitors. Bioassay results showed that among the designed compounds, derivatives 6, 13, 14, 34, 36 and 37 showed the best inhibitory activity against VV with the IC₅₀ values of 12.9, 17.9, 3.4, 2.5, 12.5 and 7.5 μm, respectively, and good cytotoxicity. The primary structure–activity relationship (SAR) study suggested that the combination of a saturated N-heterocycle, such as morpholine or 4-methylpiperidine, and a 1,7,7-trimethylbicyclo[2.2.1]heptane scaffold was favorable for antiviral activity.

Язык оригинала	английский
Номер статьи	e1800153
Число страниц	9
Журнал	Chemistry and Biodiversity
Том	15
Номер выпуска	9
DOI	https://doi.org/10.1002/cbdv.201800153
Состояние	Опубликовано - 1 сент. 2018

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10.1002/cbdv.201800153

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title = "Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor",

abstract = "A series of the bornyl ester/amide derivatives with N-containing heterocycles were designed and synthesized as vaccinia virus (VV) inhibitors. Bioassay results showed that among the designed compounds, derivatives 6, 13, 14, 34, 36 and 37 showed the best inhibitory activity against VV with the IC50 values of 12.9, 17.9, 3.4, 2.5, 12.5 and 7.5 μm, respectively, and good cytotoxicity. The primary structure–activity relationship (SAR) study suggested that the combination of a saturated N-heterocycle, such as morpholine or 4-methylpiperidine, and a 1,7,7-trimethylbicyclo[2.2.1]heptane scaffold was favorable for antiviral activity.",

keywords = "antiviral activities, borneol, monoterpenoids, N-heterocycles, orthopoxviruses, TECOVIRIMAT, EFFICACY, BORNEOL DERIVATIVES, SMALLPOX, ORTHOPOXVIRUS INFECTIONS",

author = "Sokolova, {Anastasiya S.} and Yarovaya, {Olga I.} and Bormotov, {Nikolay I.} and Shishkina, {Larisa N.} and Salakhutdinov, {Nariman F.}",

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Discovery of a New Class of Inhibitors of Vaccinia Virus Based on (−)-Borneol from Abies sibirica and (+)-Camphor. / Sokolova, Anastasiya S.; Yarovaya, Olga I.; Bormotov, Nikolay I. и др.

В: Chemistry and Biodiversity, Том 15, № 9, e1800153, 01.09.2018.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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AU - Sokolova, Anastasiya S.

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AU - Bormotov, Nikolay I.

AU - Shishkina, Larisa N.

AU - Salakhutdinov, Nariman F.

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