Development of novel efficient 2D nanocomposite catalyst towards the three-component coupling reaction for the synthesis of imidazo[1,2-a]pyridines

Najrul Hussain, Pranjal Gogoi, Manash R. Das, Pinaki Sengupta, Vladimir E. Fedorov, Igor P. Asanov, Mariia N. Kozlova, Sofya B. Artemkina

Результат исследования: Научные публикации в периодических изданияхстатья

5 Цитирования (Scopus)

Аннотация

Two dimensional (2D) materials such as graphene and functionalized hexagonal boron nitride (h-BN) supported copper catalysts (CuO/rGO, CuO/h-BN, Cu(0)/rGO, Cu(0)/h-BN, CuS/rGO and CuS/h-BN) were prepared, characterized and evaluated their catalytic activity for the synthesis of imidazo[1,2-a]pyridines via one pot three component reaction between 2-aminopyridine, aldehyde and terminal alkynes. The imidazo[1,2-a]pyridines are an imperative class of nitrogen ring containing heterocyclic compounds which has wide range of applications in medicinal chemistry and drug molecule production. The reported synthetic protocol provides a rapid access to substituted imidazo[1,2-a]pyridines with excellent yields. CuO/rGO nanocomposite material was found to be highly active catalyst for the aforementioned reaction. The advantages of our protocol for the preparation of imidazo[1,2-a]pyridines over other previously reported includes shorter reaction times, functional group tolerance, recyclable catalyst and additive-free.

Язык оригиналаанглийский
Страницы (с-по)368-379
Число страниц12
ЖурналApplied Catalysis A: General
Том542
DOI
СостояниеОпубликовано - 25 июл 2017

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