Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma

A. S. Sokolova; O. I. Yarovaya; A. A. Nefedov; N. F. Salakhutdinov

doi:10.1007/s11094-018-1748-y

Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma

A. S. Sokolova, O. I. Yarovaya, A. A. Nefedov, N. F. Salakhutdinov

Кафедра органической химии ФЕН

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

2 Цитирования (Scopus)

Аннотация

A new GC-MS method for determining an antiviral agent (camphecin) in blood plasma was developed. Sample preparation consisted of precipitating proteins using MeOH. The method was validated for selectivity, calibration curve, accuracy, precision, limit of quantitation, carryover, and stability. The analytical range was 0.1 – 2 μg/mL. The method could be used for pharmacokinetic studies.

Язык оригинала	английский
Страницы (с-по)	1102-1105
Число страниц	4
Журнал	Pharmaceutical Chemistry Journal
Том	51
Номер выпуска	12
DOI	https://doi.org/10.1007/s11094-018-1748-y
Состояние	Опубликовано - мар. 2018

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10.1007/s11094-018-1748-y

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title = "Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma",

abstract = "A new GC-MS method for determining an antiviral agent (camphecin) in blood plasma was developed. Sample preparation consisted of precipitating proteins using MeOH. The method was validated for selectivity, calibration curve, accuracy, precision, limit of quantitation, carryover, and stability. The analytical range was 0.1 – 2 μg/mL. The method could be used for pharmacokinetic studies.",

keywords = "camphecin, GC-MS, plasma, validation, A VIRUSES, ANTIVIRAL ACTIVITY, DERIVATIVES",

author = "Sokolova, {A. S.} and Yarovaya, {O. I.} and Nefedov, {A. A.} and Salakhutdinov, {N. F.}",

year = "2018",

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doi = "10.1007/s11094-018-1748-y",

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Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma. / Sokolova, A. S.; Yarovaya, O. I.; Nefedov, A. A. и др.

В: Pharmaceutical Chemistry Journal, Том 51, № 12, 03.2018, стр. 1102-1105.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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AU - Yarovaya, O. I.

AU - Nefedov, A. A.

AU - Salakhutdinov, N. F.

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KW - validation

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KW - ANTIVIRAL ACTIVITY

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