TY - JOUR
T1 - Dendriplex-Impregnated Hydrogels With Programmed Release Rate
AU - Apartsin, Evgeny
AU - Venyaminova, Alya
AU - Majoral, Jean Pierre
AU - Caminade, Anne Marie
N1 - Funding Information:
The project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 844217. This article is based on work from COST Action CA 17140 “Cancer Nanomedicine from the Bench to the Bedside” supported by the COST (European Cooperation in Science and Technology). The financial support from the CNRS is also appreciated.
Publisher Copyright:
Copyright © 2022 Apartsin, Venyaminova, Majoral and Caminade.
PY - 2022/1/5
Y1 - 2022/1/5
N2 - Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating neutral hydrogels with siRNA–dendrimer complexes. The surface chemistry of dendrimers allows adjusting the release rate of siRNA-containing complexes. This methodology can bring new materials for biomedical applications.
AB - Hydrogels are biocompatible matrices for local delivery of nucleic acids; however, functional dopants are required to provide efficient delivery into cells. In particular, dendrimers, known as robust nucleic acid carriers, can be used as dopants. Herein, we report the first example of impregnating neutral hydrogels with siRNA–dendrimer complexes. The surface chemistry of dendrimers allows adjusting the release rate of siRNA-containing complexes. This methodology can bring new materials for biomedical applications.
KW - controlled release
KW - dendrimers
KW - hydrogel
KW - oligonucleotides
KW - polyelectrolyte complexes
UR - http://www.scopus.com/inward/record.url?scp=85123100535&partnerID=8YFLogxK
U2 - 10.3389/fchem.2021.780608
DO - 10.3389/fchem.2021.780608
M3 - Article
C2 - 35071182
AN - SCOPUS:85123100535
VL - 9
JO - Frontiers in Chemistry
JF - Frontiers in Chemistry
SN - 2296-2646
M1 - 780608
ER -