Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior

G. V. Idova, E. L. Al’perina, S. Ya Zhanaeva, M. M. Gevorgyan, A. A. Rogozhnikova

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

The content of pro- and anti-inflammatory cytokines in the hypothalamus, hippocampus, and blood serum of C57Bl/6J mice with depressive-like behavior induced by 20-day social stress was analyzed in 4 h after immune stimulation with LPS (250 μg/kg). These animals are characterized by a tendency to an increase in the blood content of IL-6 and a decrease in the level of IL-10. Changes in cytokine content in the brain of mice with depressive-like state developed under these conditions were observed only in the hippocampus: the levels of IL-1β, IL-6, TNFα, and IL-10 increased and the content of IFNγ decreased in comparison the corresponding parameters in the controls (not exposed to social stress) and aggressive animals. No changes in the levels of IL-2, IL-4, and IL-17 were revealed in the hypothalamus and hippocampus.

Язык оригиналаанглийский
Страницы (с-по)11-16
Число страниц6
ЖурналBulletin of Experimental Biology and Medicine
Том167
Номер выпуска1
DOI
СостояниеОпубликовано - 15 мая 2019

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