Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior

G. V. Idova; E. L. Al’perina; S. Ya Zhanaeva; M. M. Gevorgyan; A. A. Rogozhnikova

doi:10.1007/s10517-019-04450-y

Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior

G. V. Idova, E. L. Al’perina, S. Ya Zhanaeva, M. M. Gevorgyan, A. A. Rogozhnikova

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

Аннотация

The content of pro- and anti-inflammatory cytokines in the hypothalamus, hippocampus, and blood serum of C57Bl/6J mice with depressive-like behavior induced by 20-day social stress was analyzed in 4 h after immune stimulation with LPS (250 μg/kg). These animals are characterized by a tendency to an increase in the blood content of IL-6 and a decrease in the level of IL-10. Changes in cytokine content in the brain of mice with depressive-like state developed under these conditions were observed only in the hippocampus: the levels of IL-1β, IL-6, TNFα, and IL-10 increased and the content of IFNγ decreased in comparison the corresponding parameters in the controls (not exposed to social stress) and aggressive animals. No changes in the levels of IL-2, IL-4, and IL-17 were revealed in the hypothalamus and hippocampus.

Язык оригинала	английский
Страницы (с-по)	11-16
Число страниц	6
Журнал	Bulletin of Experimental Biology and Medicine
Том	167
Номер выпуска	1
DOI	https://doi.org/10.1007/s10517-019-04450-y
Состояние	Опубликовано - 15 мая 2019

Доступ к документу

10.1007/s10517-019-04450-y

Link to publication in Scopus

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title = "Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior",

abstract = "The content of pro- and anti-inflammatory cytokines in the hypothalamus, hippocampus, and blood serum of C57Bl/6J mice with depressive-like behavior induced by 20-day social stress was analyzed in 4 h after immune stimulation with LPS (250 μg/kg). These animals are characterized by a tendency to an increase in the blood content of IL-6 and a decrease in the level of IL-10. Changes in cytokine content in the brain of mice with depressive-like state developed under these conditions were observed only in the hippocampus: the levels of IL-1β, IL-6, TNFα, and IL-10 increased and the content of IFNγ decreased in comparison the corresponding parameters in the controls (not exposed to social stress) and aggressive animals. No changes in the levels of IL-2, IL-4, and IL-17 were revealed in the hypothalamus and hippocampus.",

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Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior. / Idova, G. V.; Al’perina, E. L.; Zhanaeva, S. Ya; Gevorgyan, M. M.; Rogozhnikova, A. A.

В: Bulletin of Experimental Biology and Medicine, Том 167, № 1, 15.05.2019, стр. 11-16.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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AU - Al’perina, E. L.

AU - Zhanaeva, S. Ya

AU - Gevorgyan, M. M.

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