Crystalline form of betulin: polymorphism or pseudopolymorphism?

T. N. Drebushchak, A. V. Mikhailovskaya, V. A. Drebushchak, M. A. Mikhailenko, S. A. Myz’, T. P. Shakhtshneider, S. A. Kuznetsova

Результат исследования: Научные публикации в периодических изданияхстатья

Аннотация

By recrystallization with different solvents as well as decomposition of betulin ethanol solvate at room temperature a new crystalline form of the biologically active compound betulin, namely hemihydrate of betulin, is obtained. By single crystal X-ray diffraction data the crystal structure of hemihydrate of betulin is determined. By powder X-ray thermodiffraction and differential scanning calorimetry it is found that when hemihydrate of betulin is heated to melting, Н2О molecules are removed and solid-phase transformations occur, which are related to the formation of an intermediate crystalline form andan orthorhombic modification of betulin.

Язык оригиналаанглийский
Страницы (с-по)1260-1266
Число страниц7
ЖурналJournal of Structural Chemistry
Том61
Номер выпуска8
DOI
СостояниеОпубликовано - 1 авг 2020

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    Drebushchak, T. N., Mikhailovskaya, A. V., Drebushchak, V. A., Mikhailenko, M. A., Myz’, S. A., Shakhtshneider, T. P., & Kuznetsova, S. A. (2020). Crystalline form of betulin: polymorphism or pseudopolymorphism? Journal of Structural Chemistry, 61(8), 1260-1266. https://doi.org/10.1134/S0022476620080119