CpG islands’ clustering uncovers early development genes in the human genome

Результат исследования: Научные публикации в периодических изданияхстатья

Аннотация

We address the problem of the annotation of CpG islands (CGIs) clusters in the human genome. Upon analyzing gene content within CGIs clusters, piRNA, tRNA, and miRNA-encoding genes were found as well as CpG-rich homeobox genes reported previously. Chromosome-wide CGI density is positively correlated with replication timing, confirming that CGIs may serve as open chromatin markers. Early embryonic stage expressed KRAB-ZNF genes abundant at chromosome 19 were found to be interlinked with CGI clusters. We detected that a number of long CGIs and CGI clusters are, in fact, tandem copies with multiple annotated macrosatellites and paralogous genes. This finding implies that tandem expansion of CGIs may serve as a substrate for non-homologous recombination events.

Язык оригиналаанглийский
Страницы (с-по)473-485
Число страниц13
ЖурналComputer Science and Information Systems
Том15
Номер выпуска2
DOI
СостояниеОпубликовано - июн 2018

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