Core-Shell Magnetoactive PHB/Gelatin/Magnetite Composite Electrospun Scaffolds for Biomedical Applications

Artyom S. Pryadko, Vladimir V. Botvin, Yulia R. Mukhortova, Igor Pariy, Dmitriy V. Wagner, Pavel P. Laktionov, Vera S. Chernonosova, Boris P. Chelobanov, Roman V. Chernozem, Maria A. Surmeneva, Andrei L. Kholkin, Roman A. Surmenev

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Novel hybrid magnetoactive composite scaffolds based on poly(3-hydroxybutyrate) (PHB), gelatin, and magnetite (Fe3O4) were fabricated by electrospinning. The morphology, struc-ture, phase composition, and magnetic properties of composite scaffolds were studied. Fabrication procedures of PHB/gelatin and PHB/gelatin/Fe3O4 scaffolds resulted in the formation of both core-shell and ribbon-shaped structure of the fibers. In case of hybrid PHB/gelatin/Fe3O4 scaffolds sub-micron-sized Fe3O4 particles were observed in the surface layers of the fibers. The X-ray photoelec-tron spectroscopy results allowed the presence of gelatin on the fiber surface (N/C ratio–0.11) to be revealed. Incubation of the composite scaffolds in saline for 3 h decreased the amount of gelatin on the surface by more than ~75%. The differential scanning calorimetry results obtained for pure PHB scaffolds revealed a characteristic melting peak at 177.5 °C. The presence of gelatin in PHB/gelatin and PHB/gelatin/Fe3O4 scaffolds resulted in the decrease in melting temperature to 168–169 °C in comparison with pure PHB scaffolds due to the core-shell structure of the fibers. Hybrid scaffolds also demonstrated a decrease in crystallinity from 52.3% (PHB) to 16.9% (PHB/gelatin) and 9.2% (PHB/gelatin/Fe3O4). All the prepared scaffolds were non-toxic and saturation magnetization of the composite scaffolds with magnetite was 3.27 ± 0.22 emu/g, which makes them prospective candi-dates for usage in biomedical applications.

Язык оригиналаанглийский
Номер статьи529
ЖурналPolymers
Том14
Номер выпуска3
DOI
СостояниеОпубликовано - фев 2022

Предметные области OECD FOS+WOS

  • 2.05 ТЕХНОЛОГИЯ МАТЕРИАЛОВ
  • 1.04 ХИМИЧЕСКИЕ НАУКИ

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