Controlling Cell Death through Post-translational Modifications of DED Proteins

Kamil Seyrek, Nikita V. Ivanisenko, Max Richter, Laura K. Hillert, Corinna König, Inna N. Lavrik

Результат исследования: Научные публикации в периодических изданияхобзорная статья

Аннотация

Apoptosis is a form of programmed cell death, deregulation of which occurs in multiple disorders, including neurodegenerative and autoimmune diseases as well as cancer. The formation of a death-inducing signaling complex (DISC) and death effector domain (DED) filaments are critical for initiation of the extrinsic apoptotic pathway. Post-translational modifications (PTMs) of DED-containing DISC components such as FADD, procaspase-8, and c-FLIP comprise an additional level of apoptosis regulation, which is necessary to overcome the threshold for apoptosis induction. In this review we discuss the influence of PTMs of FADD, procaspase-8, and c-FLIP on DED filament assembly and cell death induction, with a focus on the 3D organization of the DED filament.

Язык оригиналаанглийский
Страницы (с-по)354-369
Число страниц16
ЖурналTrends in Cell Biology
Том30
Номер выпуска5
DOI
СостояниеОпубликовано - мая 2020

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