Controlling Cell Death through Post-translational Modifications of DED Proteins

Kamil Seyrek; Nikita V. Ivanisenko; Max Richter; Laura K. Hillert; Corinna König; Inna N. Lavrik

doi:10.1016/j.tcb.2020.02.006

Controlling Cell Death through Post-translational Modifications of DED Proteins

Kamil Seyrek, Nikita V. Ivanisenko, Max Richter, Laura K. Hillert, Corinna König, Inna N. Lavrik

Лаборатория молекулярной эпидемиологии и биоинформатики ИМПЗ

Результат исследования: Научные публикации в периодических изданиях › обзорная статья

Аннотация

Apoptosis is a form of programmed cell death, deregulation of which occurs in multiple disorders, including neurodegenerative and autoimmune diseases as well as cancer. The formation of a death-inducing signaling complex (DISC) and death effector domain (DED) filaments are critical for initiation of the extrinsic apoptotic pathway. Post-translational modifications (PTMs) of DED-containing DISC components such as FADD, procaspase-8, and c-FLIP comprise an additional level of apoptosis regulation, which is necessary to overcome the threshold for apoptosis induction. In this review we discuss the influence of PTMs of FADD, procaspase-8, and c-FLIP on DED filament assembly and cell death induction, with a focus on the 3D organization of the DED filament.

Язык оригинала	английский
Страницы (с-по)	354-369
Число страниц	16
Журнал	Trends in Cell Biology
Том	30
Номер выпуска	5
DOI	https://doi.org/10.1016/j.tcb.2020.02.006
Состояние	Опубликовано - мая 2020

Доступ к документу

10.1016/j.tcb.2020.02.006

Link to publication in Scopus

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Цитировать

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title = "Controlling Cell Death through Post-translational Modifications of DED Proteins",

abstract = "Apoptosis is a form of programmed cell death, deregulation of which occurs in multiple disorders, including neurodegenerative and autoimmune diseases as well as cancer. The formation of a death-inducing signaling complex (DISC) and death effector domain (DED) filaments are critical for initiation of the extrinsic apoptotic pathway. Post-translational modifications (PTMs) of DED-containing DISC components such as FADD, procaspase-8, and c-FLIP comprise an additional level of apoptosis regulation, which is necessary to overcome the threshold for apoptosis induction. In this review we discuss the influence of PTMs of FADD, procaspase-8, and c-FLIP on DED filament assembly and cell death induction, with a focus on the 3D organization of the DED filament.",

keywords = "apoptosis, DED proteins, nitrosylation, phosphorylation, SUMOylation, ubiquitylation, EXTRINSIC APOPTOSIS, ACTIVATION, PHOSPHORYLATION, MODEL, C-FLIP, DEGRADATION, CASPASE-8, FADD, UBIQUITIN-MEDIATED REGULATION, REVEALS",

author = "Kamil Seyrek and Ivanisenko, {Nikita V.} and Max Richter and Hillert, {Laura K.} and Corinna K{\"o}nig and Lavrik, {Inna N.}",

year = "2020",

month = may,

doi = "10.1016/j.tcb.2020.02.006",

language = "English",

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journal = "Trends in Cell Biology",

issn = "0962-8924",

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Controlling Cell Death through Post-translational Modifications of DED Proteins. / Seyrek, Kamil; Ivanisenko, Nikita V.; Richter, Max; Hillert, Laura K.; König, Corinna; Lavrik, Inna N.

В: Trends in Cell Biology, Том 30, № 5, 05.2020, стр. 354-369.

Результат исследования: Научные публикации в периодических изданиях › обзорная статья

TY - JOUR

T1 - Controlling Cell Death through Post-translational Modifications of DED Proteins

AU - Seyrek, Kamil

AU - Ivanisenko, Nikita V.

AU - Richter, Max

AU - Hillert, Laura K.

AU - König, Corinna

AU - Lavrik, Inna N.

PY - 2020/5

Y1 - 2020/5

N2 - Apoptosis is a form of programmed cell death, deregulation of which occurs in multiple disorders, including neurodegenerative and autoimmune diseases as well as cancer. The formation of a death-inducing signaling complex (DISC) and death effector domain (DED) filaments are critical for initiation of the extrinsic apoptotic pathway. Post-translational modifications (PTMs) of DED-containing DISC components such as FADD, procaspase-8, and c-FLIP comprise an additional level of apoptosis regulation, which is necessary to overcome the threshold for apoptosis induction. In this review we discuss the influence of PTMs of FADD, procaspase-8, and c-FLIP on DED filament assembly and cell death induction, with a focus on the 3D organization of the DED filament.

AB - Apoptosis is a form of programmed cell death, deregulation of which occurs in multiple disorders, including neurodegenerative and autoimmune diseases as well as cancer. The formation of a death-inducing signaling complex (DISC) and death effector domain (DED) filaments are critical for initiation of the extrinsic apoptotic pathway. Post-translational modifications (PTMs) of DED-containing DISC components such as FADD, procaspase-8, and c-FLIP comprise an additional level of apoptosis regulation, which is necessary to overcome the threshold for apoptosis induction. In this review we discuss the influence of PTMs of FADD, procaspase-8, and c-FLIP on DED filament assembly and cell death induction, with a focus on the 3D organization of the DED filament.

KW - apoptosis

KW - DED proteins

KW - nitrosylation

KW - phosphorylation

KW - SUMOylation

KW - ubiquitylation

KW - EXTRINSIC APOPTOSIS

KW - ACTIVATION

KW - PHOSPHORYLATION

KW - MODEL

KW - C-FLIP

KW - DEGRADATION

KW - CASPASE-8

KW - FADD

KW - UBIQUITIN-MEDIATED REGULATION

KW - REVEALS

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U2 - 10.1016/j.tcb.2020.02.006

DO - 10.1016/j.tcb.2020.02.006

M3 - Review article

C2 - 32302548

AN - SCOPUS:85082821770

VL - 30

SP - 354

EP - 369

JO - Trends in Cell Biology

JF - Trends in Cell Biology

SN - 0962-8924

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