Comprehensive analysis of telomerase inhibition by gallotannin

Nikita Savelyev, Polina Baykuzina, Svetlana Dokudovskaya, Olga Lavrik, Maria Rubtsova, Olga Dontsova

Результат исследования: Научные публикации в периодических изданияхстатья

4 Цитирования (Scopus)

Аннотация

Gallotannin (or tannic acid) is a naturally occurring compound that inhibits cell growth and activity of different DNA-polymerases, including telomerase. The purpose of the present study was to gain insight into the mechanism of telomerase inhibition by gallotannin. We determined that gallotannin inhibits telomerase in vitro with an half maximal inhibitory concentrations value of 130 nM, but it does not affect telomerase complex assembly and component levels in vivo. The inhibitory activity of gallotannin against telomerase provides an additional explanation for the anti-cancer activities of this compound.

Язык оригиналаанглийский
Страницы (с-по)18712-18719
Число страниц8
ЖурналOncotarget
Том9
Номер выпуска27
DOI
СостояниеОпубликовано - 10 апр 2018

Fingerprint Подробные сведения о темах исследования «Comprehensive analysis of telomerase inhibition by gallotannin». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать

    Savelyev, N., Baykuzina, P., Dokudovskaya, S., Lavrik, O., Rubtsova, M., & Dontsova, O. (2018). Comprehensive analysis of telomerase inhibition by gallotannin. Oncotarget, 9(27), 18712-18719. https://doi.org/10.18632/oncotarget.24642