Аннотация
A series of secondary amines combining monoterpenoid and aminoadamantane moieties have been synthesized. Their cytotoxic activity against human cancer cells CEM-13, MT-4, and U-937 has been studied for the first time. Most of the obtained compounds exhibited a significant cytotoxic activity with the median cytotoxic dose (CTD50) ranging from 6 to 84 μM. The most promising results were obtained for compound 2b which was synthesized from 1-aminoadamantane and (-)-myrtenal and revealed a high activity against all tumor lines used (CTD50= 12/21 μM) along with low toxicity with respect to MDCK cells (CTD50= 1500 μM). The synthesized amines do not exert the genotoxic effect on cells of the biosensor strain based on recombinant E. coli cells bearing the pRAC-gfp plasmid.
Язык оригинала | английский |
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Страницы (с-по) | 629-635 |
Число страниц | 7 |
Журнал | Medicinal Chemistry |
Том | 11 |
Номер выпуска | 7 |
DOI | |
Состояние | Опубликовано - 1 окт 2015 |