Compounds Combining Aminoadamantane and Monoterpene Moieties: Cytotoxicity and Mutagenic Effects

Evgeniy V. Suslov, Konstantin Yu. Ponomarev, Artem D. Rogachev, Michail A. Pokrovsky, Andrey G. Pokrovsky, Maria B. Pykhtina, Anatoly B. Beklemishev, Dina V. Korchagina, Konstantin P. Volcho, Nariman F. Salakhutdinov

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

A series of secondary amines combining monoterpenoid and aminoadamantane moieties have been synthesized. Their cytotoxic activity against human cancer cells CEM-13, MT-4, and U-937 has been studied for the first time. Most of the obtained compounds exhibited a significant cytotoxic activity with the median cytotoxic dose (CTD50) ranging from 6 to 84 mu M. The most promising results were obtained for compound 2b which was synthesized from 1-aminoadamantane and (-)-myrtenal and revealed a high activity against all tumor lines used (CTD50 = 12 divided by 21 mu M) along with low toxicity with respect to MDCK cells (CTD50 = 1500 mu M). The synthesized amines do not exert the genotoxic effect on cells of the biosensor strain based on recombinant E. coli cells bearing the pRAC-gfp plasmid.

Язык оригиналаанглийский
Страницы (с-по)629-635
Число страниц7
ЖурналMedicinal Chemistry
Том11
Номер выпуска7
DOI
СостояниеОпубликовано - 2015

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