Comparison of intravenous toxicity of hexaniobium cluster complex and its conjugate with gamma-cyclodextrin

Tatiana Pozmogova, Valentina Evsiukova, Anton Ivanov, Pavel Abramov, Yuri Vorotnikov, Anastsia Solovieva, Andrey Kushnarenko, Michael Shestopalov

Результат исследования: Публикации в книгах, отчётах, сборниках, трудах конференцийстатья в сборнике материалов конференциинаучнаярецензирование

Аннотация

Cyclodextrins and their derivatives are widely used as drug delivery agents due to their ability to hold small molecules in their internal cavity. Reduction of toxicity by cyclodextrins is proven in the case of non-invasive or oral delivery of drugs, but the authors disagree on the intravenous use of these substances. In this paper, we compare two substances-the cluster complex of niobium [Nb6Cl12(H2O)6]2+ for which we previously showed anticancer activity, and its conjugate with cyclodextrin [Nb6Cl12(H2O)6]2+@\gamma-CD. To assess the effect of cyclodextrin on the toxicity of the solution, we intravenously administered a wide range of doses of two substances to BALB/C mice. After assessment of acute toxicity, the study of organ morphology was carried out. The results showed that conjugation with cyclodextrin not only did not reduce the toxicity of the cluster complex, but also increased it, causing vascular disorders in several organs.

Язык оригиналаанглийский
Название основной публикацииSIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings
ИздательInstitute of Electrical and Electronics Engineers Inc.
Страницы326-329
Число страниц4
ISBN (электронное издание)9781728144016
DOI
СостояниеОпубликовано - окт 2019
Событие2019 International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2019 - Novosibirsk, Российская Федерация
Продолжительность: 21 окт 201927 окт 2019

Серия публикаций

НазваниеSIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings

Конференция

Конференция2019 International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2019
СтранаРоссийская Федерация
ГородNovosibirsk
Период21.10.201927.10.2019

Fingerprint Подробные сведения о темах исследования «Comparison of intravenous toxicity of hexaniobium cluster complex and its conjugate with gamma-cyclodextrin». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать

    Pozmogova, T., Evsiukova, V., Ivanov, A., Abramov, P., Vorotnikov, Y., Solovieva, A., Kushnarenko, A., & Shestopalov, M. (2019). Comparison of intravenous toxicity of hexaniobium cluster complex and its conjugate with gamma-cyclodextrin. В SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings (стр. 326-329). [8958429] (SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/SIBIRCON48586.2019.8958429