Comparative Subpopulation Analysis of Plasma Exosomes from Cancer Patients

S. N. Tamkovich; N. V. Yunusova; A. K. Somov; S. G. Afanas’ev; G. V. Kakurina; E. S. Kolegova; E. A. Tugutova; P. P. Laktionov; I. V. Kondakova

doi:10.1134/S1990750818020130

Comparative Subpopulation Analysis of Plasma Exosomes from Cancer Patients

S. N. Tamkovich, N. V. Yunusova, A. K. Somov, S. G. Afanas’ev, G. V. Kakurina, E. S. Kolegova, E. A. Tugutova, P. P. Laktionov, I. V. Kondakova

Кафедра молекулярной биологии и биотехнологии

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

6 Цитирования (Scopus)

Аннотация

Pre-selection of tumor exosomes from a total pool of circulating microvesicles is an important stage required to increase sensitivity and specificity of the developing methods for diagnostics of oncological diseases. In this study, universal proteins characterized by increased expression in plasma exosomes have been identified in patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will help to develop a simple and high-performance method of affinity isolation of tumor exosomes.

Язык оригинала	английский
Страницы (с-по)	151-155
Число страниц	5
Журнал	Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Том	12
Номер выпуска	2
DOI	https://doi.org/10.1134/S1990750818020130
Состояние	Опубликовано - 1 апр 2018

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10.1134/S1990750818020130

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title = "Comparative Subpopulation Analysis of Plasma Exosomes from Cancer Patients",

abstract = "Pre-selection of tumor exosomes from a total pool of circulating microvesicles is an important stage required to increase sensitivity and specificity of the developing methods for diagnostics of oncological diseases. In this study, universal proteins characterized by increased expression in plasma exosomes have been identified in patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will help to develop a simple and high-performance method of affinity isolation of tumor exosomes.",

keywords = "colorectal cancer, exosomes, flow cytometry, head and neck squamous cell carcinoma, lung cancer, protein spectrum, transmission electron microscopy",

author = "Tamkovich, {S. N.} and Yunusova, {N. V.} and Somov, {A. K.} and Afanas{\textquoteright}ev, {S. G.} and Kakurina, {G. V.} and Kolegova, {E. S.} and Tugutova, {E. A.} and Laktionov, {P. P.} and Kondakova, {I. V.}",

year = "2018",

month = apr,

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doi = "10.1134/S1990750818020130",

language = "English",

volume = "12",

pages = "151--155",

journal = "Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry",

issn = "1990-7508",

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number = "2",

}

Comparative Subpopulation Analysis of Plasma Exosomes from Cancer Patients. / Tamkovich, S. N.; Yunusova, N. V.; Somov, A. K.; Afanas’ev, S. G.; Kakurina, G. V.; Kolegova, E. S.; Tugutova, E. A.; Laktionov, P. P.; Kondakova, I. V.

В: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, Том 12, № 2, 01.04.2018, стр. 151-155.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

TY - JOUR

T1 - Comparative Subpopulation Analysis of Plasma Exosomes from Cancer Patients

AU - Tamkovich, S. N.

AU - Yunusova, N. V.

AU - Somov, A. K.

AU - Afanas’ev, S. G.

AU - Kakurina, G. V.

AU - Kolegova, E. S.

AU - Tugutova, E. A.

AU - Laktionov, P. P.

AU - Kondakova, I. V.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Pre-selection of tumor exosomes from a total pool of circulating microvesicles is an important stage required to increase sensitivity and specificity of the developing methods for diagnostics of oncological diseases. In this study, universal proteins characterized by increased expression in plasma exosomes have been identified in patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will help to develop a simple and high-performance method of affinity isolation of tumor exosomes.

AB - Pre-selection of tumor exosomes from a total pool of circulating microvesicles is an important stage required to increase sensitivity and specificity of the developing methods for diagnostics of oncological diseases. In this study, universal proteins characterized by increased expression in plasma exosomes have been identified in patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will help to develop a simple and high-performance method of affinity isolation of tumor exosomes.

KW - colorectal cancer

KW - exosomes

KW - flow cytometry

KW - head and neck squamous cell carcinoma

KW - lung cancer

KW - protein spectrum

KW - transmission electron microscopy

UR - http://www.scopus.com/inward/record.url?scp=85047834580&partnerID=8YFLogxK

U2 - 10.1134/S1990750818020130

DO - 10.1134/S1990750818020130

M3 - Article

AN - SCOPUS:85047834580

VL - 12

SP - 151

EP - 155

JO - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

JF - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

SN - 1990-7508

IS - 2

ER -

Comparative Subpopulation Analysis of Plasma Exosomes from Cancer Patients

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