Chemical approach to the design of effective antidiabetic agents

The review discusses the literature data on the structures of hypoglycemic compounds with different mechanisms of action. It is shown that many drugs acting on different biological targets have similar or identical structural moieties. Compounds containing a sulfonyl group, a 3-phenylpropanoic acid moiety or the indane ring, as well as derivatives of heterocyclic systems (quinoline, isoquinoline, benzoxazine, thiazolidine and so on) are presented. The approach to the design of multi target hypoglycemic drugs by combining different pharmacophoric groups in one molecule is considered. The prospects of the use of these agents for the treatment of type 2 diabetes are discussed.

The bibliography includes 177 references.