Characteristics of p-type and n-type photoelectrochemical biosensors: A case study for esophageal cancer detection

Joseph Hang Leung, Hong Thai Nguyen, Shih Wei Feng, Sofya B. Artemkina, Vladimir E. Fedorov, Shang Chin Hsieh, Hsiang Chen Wang

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

P-type and N-type photoelectrochemical (PEC) biosensors were established in the laboratory to discuss the correlation between characteristic substances and photoactive material properties through the photogenerated charge carrier transport mechanism. Four types of human esophageal cancer cells (ECCs) were analyzed without requiring additional bias voltage. Photoelectrical characteristics were examined by scanning electron microscopy (SEM), X-ray diffraction (XRD), UV–vis reflectance spectroscopy, and photocurrent response analyses. Results showed that smaller pho-tocurrent was measured in cases with advanced cancer stages. Glutathione (L-glutathione reduced, GSH) and Glutathione disulfide (GSSG) in cancer cells carry out redox reactions during carrier separation, which changes the photocurrent. The sensor can identify ECC stages with a certain level of photoelectrochemical response. The detection error can be optimized by adjusting the number of cells, and the detection time of about 5 min allowed repeated measurement.

Язык оригиналаанглийский
Номер статьи1065
ЖурналNanomaterials
Том11
Номер выпуска5
DOI
СостояниеОпубликовано - мая 2021

Предметные области OECD FOS+WOS

  • 2.05 ТЕХНОЛОГИЯ МАТЕРИАЛОВ
  • 2.04 ХИМИЧЕСКИЕ ТЕХНОЛОГИИ

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