CAR T-cell therapy: Balance of efficacy and safety

S. V. Kulemzin, V. V. Kuznetsova, M. Mamonkin, A. V. Taranin, A. A. Gorchakov

Результат исследования: Научные публикации в периодических изданияхобзорная статья

2 Цитирования (Scopus)

Аннотация

Early results from clinical trials of autologous chimeric antigen receptor (CAR)-expressing T cells for the therapy of B-cell malignancies have encouraged extending the potency of this therapy to other cancers. However, the success of using CAR T-cells to treat patients with solid tumors has been limited. In this review, we summarize current knowledge on the design and applications of CARs for the targeted therapy of cancer. We describe existing issues that limit the widespread application of CAR T cells and discuss the optimization steps needed to further improve safety and efficacy of this therapeutic platform.

Язык оригиналаанглийский
Страницы (с-по)274-287
Число страниц14
ЖурналMolekuliarnaia biologiia
Том51
Номер выпуска2
DOI
СостояниеОпубликовано - 26 мая 2017

Ключевые слова

  • Animals
  • Hematologic Neoplasms/genetics
  • Humans
  • Immunotherapy/methods
  • Oncogene Proteins, Fusion/genetics
  • Receptors, Antigen, T-Cell/genetics
  • T-Lymphocytes/immunology

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  • Цитировать

    Kulemzin, S. V., Kuznetsova, V. V., Mamonkin, M., Taranin, A. V., & Gorchakov, A. A. (2017). CAR T-cell therapy: Balance of efficacy and safety. Molekuliarnaia biologiia, 51(2), 274-287. https://doi.org/10.7868/S0026898417020148