Calcium Administration During Weaning From Cardiopulmonary Bypass: A Narrative Literature Review

Vladimir V. Lomivorotov, Elizaveta A. Leonova, Alessandro Belletti, Vladimir A. Shmyrev, Giovanni Landoni

Результат исследования: Научные публикации в периодических изданияхобзорная статья

Выдержка

The search for safe and effective patient management strategies during weaning from cardiopulmonary bypass is ongoing; intravenous calcium is occasionally used as a first-line drug. The physiologic role of calcium suggests that it can support the function of the cardiovascular system during this critical period. Patients may be mildly hypocalcemic after cardiopulmonary bypass; however, this degree of hypocalcemia does not significantly impair the cardiovascular system. The transient beneficial effects of calcium administration (increase in arterial blood pressure, systemic vascular resistance, cardiac index, stroke volume, and coronary perfusion pressure) might be helpful in cases of moderate contractility reduction or vasoplegia. Nonetheless, effects on clinically relevant endpoints are unknown, and possible systemic side effects, such as transient reduction in internal mammary artery graft flow, attenuation of the effects of β-sympathomimetics, “stone heart” phenomenon, and pancreatic cellular injury, may limit the use of calcium salts. Further studies are needed to expand the understanding of the effects of calcium administration on patient outcomes.

Язык оригиналаанглийский
Страницы (с-по)235-244
Число страниц10
ЖурналJournal of Cardiothoracic and Vascular Anesthesia
Том34
Номер выпуска1
Ранняя дата в режиме онлайн17 июн 2018
DOI
СостояниеОпубликовано - янв 2020

Отпечаток

Weaning
Cardiopulmonary Bypass
Calcium
Cardiovascular System
Vasoplegia
Sympathomimetics
Mammary Arteries
Hypocalcemia
Vascular Resistance
Stroke Volume
Arterial Pressure
Perfusion
Salts
Transplants
Pressure
Wounds and Injuries
Pharmaceutical Preparations

Цитировать

Lomivorotov, Vladimir V. ; Leonova, Elizaveta A. ; Belletti, Alessandro ; Shmyrev, Vladimir A. ; Landoni, Giovanni. / Calcium Administration During Weaning From Cardiopulmonary Bypass : A Narrative Literature Review. В: Journal of Cardiothoracic and Vascular Anesthesia. 2020 ; Том 34, № 1. стр. 235-244.
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abstract = "The search for safe and effective patient management strategies during weaning from cardiopulmonary bypass is ongoing; intravenous calcium is occasionally used as a first-line drug. The physiologic role of calcium suggests that it can support the function of the cardiovascular system during this critical period. Patients may be mildly hypocalcemic after cardiopulmonary bypass; however, this degree of hypocalcemia does not significantly impair the cardiovascular system. The transient beneficial effects of calcium administration (increase in arterial blood pressure, systemic vascular resistance, cardiac index, stroke volume, and coronary perfusion pressure) might be helpful in cases of moderate contractility reduction or vasoplegia. Nonetheless, effects on clinically relevant endpoints are unknown, and possible systemic side effects, such as transient reduction in internal mammary artery graft flow, attenuation of the effects of β-sympathomimetics, “stone heart” phenomenon, and pancreatic cellular injury, may limit the use of calcium salts. Further studies are needed to expand the understanding of the effects of calcium administration on patient outcomes.",
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Calcium Administration During Weaning From Cardiopulmonary Bypass : A Narrative Literature Review. / Lomivorotov, Vladimir V.; Leonova, Elizaveta A.; Belletti, Alessandro; Shmyrev, Vladimir A.; Landoni, Giovanni.

В: Journal of Cardiothoracic and Vascular Anesthesia, Том 34, № 1, 01.2020, стр. 235-244.

Результат исследования: Научные публикации в периодических изданияхобзорная статья

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AU - Lomivorotov, Vladimir V.

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AU - Shmyrev, Vladimir A.

AU - Landoni, Giovanni

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N2 - The search for safe and effective patient management strategies during weaning from cardiopulmonary bypass is ongoing; intravenous calcium is occasionally used as a first-line drug. The physiologic role of calcium suggests that it can support the function of the cardiovascular system during this critical period. Patients may be mildly hypocalcemic after cardiopulmonary bypass; however, this degree of hypocalcemia does not significantly impair the cardiovascular system. The transient beneficial effects of calcium administration (increase in arterial blood pressure, systemic vascular resistance, cardiac index, stroke volume, and coronary perfusion pressure) might be helpful in cases of moderate contractility reduction or vasoplegia. Nonetheless, effects on clinically relevant endpoints are unknown, and possible systemic side effects, such as transient reduction in internal mammary artery graft flow, attenuation of the effects of β-sympathomimetics, “stone heart” phenomenon, and pancreatic cellular injury, may limit the use of calcium salts. Further studies are needed to expand the understanding of the effects of calcium administration on patient outcomes.

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