BNCT for veterinary medicine

Результат исследования: Публикации в книгах, отчётах, сборниках, трудах конференцийстатья в сборнике материалов конференциинаучнаярецензирование

Аннотация

We provided clinical veterinary BNCT studies in cats and dogs with spontaneous malignant tumors on accelerator based epithermal neutron source at Budker Institute of Nuclear Physics in Novosibirsk, Russia and IRT-T research reactor at National Research Tomsk Polytechnic University in Tomsk, Russia. These animals were selected for this method of therapy due to the impossibility of performing surgical treatment and other methods of therapy. BSH (Katchem, Czech Republic) was used as boron compound at a dose of 100 mg / kg, intravenous infusion lasting 1 hour. Before and after irradiation, blood samples were taken from the animal to study the boron concentration with an ICPE-9820 atomic emission spectrometer (Shimadzu, Japan). A preliminary calculation of the dose in the tumor and skin was carried out using the tomography data by the Monte Carlo method. In all cases, we observed partial tumor response, clinical benefit, and an increase in estimated survival time when recruited with excellent quality of life. Treatment-related toxicity was mild and reversible. These studies contribute to the preparation for clinical trials of BNCT for the treatment malignant tumors in Russia and suggest a potential role for BNCT in veterinary medicine.
Язык оригиналаанглийский
Название основной публикации19th International Congress on Neutron Capture Therapy Granada, Spain, September 27th - October 1st, 2021. Book of Abstacts
Место публикацииВена
ИздательInternational Atomic Energy Agency
Страницы159
Число страниц1
СостояниеОпубликовано - 2021
Событие19th International Congress on Neutron Capture Therapy - Вена, Австрия
Продолжительность: 27 сен 20211 окт 2021
Номер конференции: 19
http://www.icnct19.org/

Конференция

Конференция19th International Congress on Neutron Capture Therapy
Сокращенный заголовокICNCT
СтранаАвстрия
ГородВена
Период27.09.202101.10.2021
Адрес в сети Интернет

Предметные области OECD FOS+WOS

  • 2.02.IQ ИНЖЕНЕРИЯ, ЭЛЕКТРИЧЕСКАЯ И ЭЛЕКТРОННАЯ

ГРНТИ

  • 47.31 Ускорители заряженных частиц и плазмы

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